Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11261519 | 0.85 | LMNA (0.52) | LMNACYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17268233 | 0.79 | GABRA1 (0.45) | GPR84CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9463681 | 0.77 | LMNA (0.48) | LMNAPDE2AAOC3TSHR | |
| SCHEMBL430273 | 0.73 | PDE4A (0.46) | CYP2D6SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL29583446 | 0.73 | PDE4A (0.46) | CYP2D6SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3418792 | 0.72 | CYP2C9 (0.50) | LMNASLC6A4KMT2ACYP1A2AOC3 | |
| SCHEMBL3929537 | 0.72 | CYP2C9 (0.50) | LMNASLC6A4KMT2ACYP1A2AOC3 | |
| SCHEMBL22288132 | 0.71 | LMNA (0.42) | LMNAGPR84CYP2D6MEN1KMT2A | |
| SCHEMBL5107136 | 0.71 | LMNA (0.61) | LMNACYP2D6PDE2AAOC3TSHR | |
| SCHEMBL30172716 | 0.71 | LMNA (0.61) | LMNACYP2D6PDE2AAOC3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351842-A | N-Cyclopropylisoindolines | GLAXO LABORATORIES LIMITED (GB) | 1982-09-28 | — | — | US | disclosed |