Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11245134 | 0.98 | HTR1A (0.37) | HTR1ADRD2HTR2AHRH1DRD3 | |
| SCHEMBL11253381 | 0.80 | HTR2B (0.45) | HTR1ADRD2HTR2AHRH1DRD3 | |
| SCHEMBL11268855 | 0.78 | POLB (0.31) | — | |
| SCHEMBL11249497 | 0.77 | HTR7 (0.39) | — | |
| SCHEMBL6971705 | 0.74 | HTR7 (0.35) | SMN1; SMN2 | |
| SCHEMBL3071129 | 0.73 | TP53 (0.34) | — | |
| Hydrochloric Acid SCHEMBL11250722 | 0.71 | TP53 (0.33) | — | |
| SCHEMBL11251647 | 0.70 | NPY1R (0.39) | SMN1; SMN2 | |
| SCHEMBL22800555 | 0.66 | PLAT (0.33) | — | |
| SCHEMBL3379242 | 0.65 | SMN1; SMN2 (0.46) | HTR1ADRD2HTR2AHRH1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309541-A | CHEMICAL INTERMEDIATES TO QUINAZOLINE HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |
| US-4255429-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| EP-0009465-A1 | N-(1-(4-amino-2-quinazolinyl)-3 or 4-piperidyl lactames, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-04-02 | — | — | EP | disclosed |