Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003984 | 0.87 | KMT2A (0.72) | KMT2AL3MBTL1CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL11263287 | 0.87 | KMT2A (0.48) | KMT2ACYP3A4CYP2C19ALDH1A1PTGS1 | |
| SCHEMBL11269251 | 0.85 | KMT2A (0.48) | KMT2AL3MBTL1TDP1CYP3A4ALDH1A1 | |
| SCHEMBL13158249 | 0.85 | L3MBTL1 (0.50) | KMT2AL3MBTL1TDP1CYP3A4ALDH1A1 | |
| SCHEMBL11259340 | 0.81 | KMT2A (0.41) | KMT2AL3MBTL1TDP1CYP3A4CYP2C19 | |
| SCHEMBL27484082 | 0.81 | KMT2A (0.62) | KMT2AL3MBTL1TDP1CYP3A4CYP2C19 | |
| SCHEMBL11261799 | 0.80 | SMN1; SMN2 (0.49) | KMT2ACYP2C19ALDH1A1PTGS1PTGS2 | |
| SCHEMBL11266686 | 0.80 | KMT2A (0.50) | KMT2ACYP3A4CYP2C19ALDH1A1LMNA | |
| SCHEMBL11272950 | 0.79 | ALDH1A1 (0.49) | KMT2ACYP3A4CYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL3236310 | 0.77 | KMT2A (0.56) | KMT2ACYP3A4CYP2C19ALDH1A1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360520-A | 1,4-Dihydropyridazine compounds, and their medicinal use | BAYER AKTIENGESELLSCHAFT (DE) | 1982-11-23 | — | — | US | disclosed |
| EP-0001108-B1 | 1,4-DIHYDROPYRIDAZINES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICALS | BAYER AG (DE) | 1981-04-29 | — | — | EP | disclosed |
| EP-0001108-A1 | 1,4-Dihydropyridazines, process for their preparation and their use in pharmaceuticals | BAYER AG (DE) | 1979-03-21 | — | — | EP | disclosed |