Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11265313 | 0.87 | HPGD (0.42) | KMT2AHPGDPOLBNPC1RAB9A | |
| SCHEMBL11260852 | 0.83 | OPRM1 (0.46) | KMT2AHPGDPOLBCYP2C19NPC1 | |
| SCHEMBL11262310 | 0.80 | KMT2A (0.59) | KMT2APOLBCYP2C19CYP3A4NPC1 | |
| SCHEMBL2003984 | 0.80 | KMT2A (0.72) | KMT2APOLBCYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL21551769 | 0.74 | POLB (0.49) | KMT2APOLBCYP2C19NPC1RAB9A | |
| SCHEMBL28427974 | 0.74 | CES2 (0.51) | KMT2APOLBCYP2C19NPC1RAB9A | |
| SCHEMBL15163429 | 0.72 | HPGD (0.56) | KMT2AHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11263287 | 0.72 | KMT2A (0.48) | KMT2AHPGDCYP2C19CYP3A4NPC1 | |
| SCHEMBL3236310 | 0.70 | KMT2A (0.56) | KMT2ACYP2C19CYP3A4ALDH1A1LMNA | |
| SCHEMBL11496475 | 0.70 | ALDH1A1 (0.58) | HPGDPOLBCYP2C19NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360520-A | 1,4-Dihydropyridazine compounds, and their medicinal use | BAYER AKTIENGESELLSCHAFT (DE) | 1982-11-23 | — | — | US | disclosed |