Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3882921 | 0.78 | AKT1 (0.40) | NOTUMGAAMEN1KMT2A | |
| SCHEMBL30288133 | 0.78 | AKT1 (0.40) | NOTUMGAAMEN1KMT2A | |
| SCHEMBL30783445 | 0.77 | AHR (0.38) | NOTUMNPSR1 | |
| SCHEMBL25166448 | 0.75 | KDM4E (0.32) | NOTUMGAAMEN1KMT2A | |
| SCHEMBL9088450 | 0.75 | AKT1 (0.42) | — | |
| SCHEMBL31472199 | 0.74 | NOTUM (0.32) | NOTUMHPGDNPSR1 | |
| SCHEMBL30451991 | 0.74 | NOTUM (0.38) | NOTUM | |
| SCHEMBL24252953 | 0.74 | NOTUM (0.38) | NOTUM | |
| SCHEMBL24662927 | 0.74 | GAA (0.37) | NOTUMGAA | |
| SCHEMBL19814236 | 0.74 | ACHE (0.32) | MEN1HPGDKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361573-A | α,α-Diaryl-β-(tert-amino)-propanols and diuretic pharmaceutical compositions containing them | TEMMLER AG (CH) | 1982-11-30 | — | — | US | disclosed |
| US-4025633-A | DIURETICS, SALURETICS | FIRMA TEMMLER A.G. (CH) | 1977-05-24 | — | — | US | disclosed |