Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263235 | 1.00 | GAA (0.47) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL12960706 | 0.90 | GAA (0.47) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL12006858 | 0.90 | GAA (0.47) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL4127868 | 0.90 | GAA (0.47) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL12013632 | 0.90 | GAA (0.47) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL14768978 | 0.82 | GAA (0.66) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL10222582 | 0.82 | GAA (0.66) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL11497217 | 0.82 | OPRM1 (0.35) | GAACYP3A4CYP2D6OPRD1SLC22A1 | |
| SCHEMBL11262516 | 0.82 | MAPT (0.44) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL11364379 | 0.82 | MAPT (0.44) | GAAMAPTMRGPRX2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023576-B1 | 7- AND 7,8-SUBSTITUTED 4,5-ALPHA-EPOXYMORPHINAN-6-ONES AND THERAPEUTICALLY ACTIVE COMPOSITIONS CONTAINING THEM | MILES LABORATORIES, INC. (US) | 1982-06-23 | — | — | EP | disclosed |
| US-4272541-A | 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them | MILES LABORATORIES, INC. (US) | 1981-06-09 | — | — | US | disclosed |
| EP-0023576-A1 | 7- and 7,8-substituted 4,5-alpha-epoxymorphinan-6-ones and therapeutically active compositions containing them | MILES LABORATORIES, INC. (US) | 1981-02-11 | — | — | EP | disclosed |