Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12960706 | 1.00 | GAA (0.47) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL12006858 | 1.00 | GAA (0.47) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL12013632 | 1.00 | GAA (0.47) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL11263235 | 0.90 | GAA (0.47) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL11263244 | 0.90 | GAA (0.47) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL12929674 | 0.89 | SLC22A1 (0.37) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL13321579 | 0.86 | SLC22A1 (0.35) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL14768978 | 0.82 | GAA (0.66) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL10222582 | 0.82 | GAA (0.66) | GAAMAPTMRGPRX2CYP3A4CYP2D6 | |
| SCHEMBL12646217 | 0.81 | OPRM1 (0.36) | MAPTMRGPRX2CYP3A4CYP2D6OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120116086-A1 | Sinomenine Derivatives and Processes for their Synthesis | MALLINCKRODT LLC (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120116086-A1 | Sinomenine Derivatives and Processes for their Synthesis | MALLINCKRODT LLC (US) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120116086-A1 | Sinomenine Derivatives and Processes for their Synthesis | SMS, SARM1, XPO5 | GAA 2857/4885MAPT 1535/4885MRGPRX2 1623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.