Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 10/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346457 | 0.92 | FGFR3 (0.38) | FGFR3HDAC1ADORA2AADORA1IMPDH2 | |
| SCHEMBL12678257 | 0.84 | HRH3 (0.46) | FGFR3HRH3KDR | |
| SCHEMBL3352671 | 0.84 | FGFR3 (0.44) | FGFR3ADORA2AADORA1HRH3PTGES | |
| SCHEMBL1127069 | 0.83 | FGFR3 (0.49) | FGFR3PTGESKDR | |
| SCHEMBL1126571 | 0.83 | FGFR3 (0.42) | FGFR3PTGES | |
| SCHEMBL3346853 | 0.83 | FGFR3 (0.48) | FGFR3HDAC1ADORA2AADORA1 | |
| SCHEMBL3348914 | 0.76 | FGFR3 (0.42) | FGFR3PTGES | |
| SCHEMBL17023135 | 0.73 | FAAH (0.53) | HRH3 | |
| SCHEMBL1126140 | 0.71 | HRH3 (0.53) | FGFR3HRH3KDR | |
| SCHEMBL17023080 | 0.70 | HSP90AA1 (0.38) | FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2011-02-16 | — | — | EP | claimed |