SCHEMBL17023135

SCHEMBL17023135

CN(C)CCOc1ccc(NC(=O)Oc2ccc(-c3ccccc3F)c3nccnc23)cc1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FAAH O00519 15/20 0.53
HRH3 Q9Y5N1 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12678257 0.86 HRH3 (0.46) FAAHHRH3
SCHEMBL17023123 0.84 HRH3 (0.52) FAAHHRH3
SCHEMBL17023109 0.83 HRH3 (0.41) FAAHHRH3
SCHEMBL17023106 0.81 HRH3 (0.47) HRH3
SCHEMBL17023093 0.79 FGFR3 (0.55) HRH3
SCHEMBL17023080 0.74 HSP90AA1 (0.38) FAAH
SCHEMBL1126337 0.73 FGFR3 (0.42) HRH3
SCHEMBL1126140 0.69 HRH3 (0.53) HRH3
SCHEMBL1126690 0.69 FGFR3 (0.51) HRH3
SCHEMBL5218224 0.68 FAAH (1.00) FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2282995-B1 DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS NOVARTIS AG (CH) 2015-08-26 EP claimed