Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 10/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | PAICS | P22234 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 4/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348914 | 0.91 | FGFR3 (0.42) | FGFR3HPGDSPAICSPTGESSCN10A | |
| SCHEMBL1126508 | 0.88 | HPGDS (0.49) | FGFR3HPGDSPTGESSCN10ASCN1A | |
| SCHEMBL12678307 | 0.85 | FGFR3 (0.52) | FGFR3KDR | |
| SCHEMBL1126337 | 0.83 | FGFR3 (0.42) | FGFR3PTGESKDR | |
| SCHEMBL3352671 | 0.81 | FGFR3 (0.44) | FGFR3PTGESKDR | |
| SCHEMBL3346853 | 0.78 | FGFR3 (0.48) | FGFR3HPGDS | |
| SCHEMBL3346457 | 0.76 | FGFR3 (0.38) | FGFR3 | |
| SCHEMBL17023037 | 0.75 | HPGDS (0.44) | FGFR3HPGDSPTGESSCN10ASCN1A | |
| SCHEMBL17023106 | 0.75 | HRH3 (0.47) | FGFR3PAICSKDR | |
| SCHEMBL3350442 | 0.73 | FGFR3 (0.54) | FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2011-02-16 | — | — | EP | claimed |