Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 8/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10963912 | 0.83 | OPRK1 (0.79) | OPRK1HPGDOPRD1ADRB1 | |
| SCHEMBL10963938 | 0.82 | OPRK1 (0.41) | OPRK1HPGDLMNAPDE4DCHRM1 | |
| SCHEMBL11147029 | 0.69 | OPRK1 (0.81) | OPRK1HPGDLMNAOPRD1HTT | |
| SCHEMBL10969329 | 0.68 | LMNA (0.58) | OPRK1HPGDLMNAPDE4DCHRM1 | |
| SCHEMBL10965338 | 0.66 | OPRK1 (0.68) | OPRK1LMNAOPRD1 | |
| SCHEMBL11352761 | 0.66 | OPRK1 (0.42) | OPRK1HPGDLMNAPDE4DCHRM1 | |
| SCHEMBL11395623 | 0.64 | OPRK1 (0.40) | OPRK1HPGDLMNAPDE4DCHRM1 | |
| SCHEMBL10966464 | 0.63 | OPRK1 (0.70) | OPRK1OPRD1 | |
| SCHEMBL10861062 | 0.62 | CCKBR (0.67) | OPRK1OPRD1 | |
| SCHEMBL10964736 | 0.61 | OPRK1 (0.66) | OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0054839-A2 | 2-Acylaminomethyl-1,4-benzodiazepines and their salts, methods of preparing them and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1982-06-30 | — | — | EP | disclosed |