Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11255464 | 0.78 | POLB (0.49) | ADRA2AADRA1ACYP2D6MEN1KMT2A | |
| SCHEMBL19389253 | 0.77 | CYP2D6 (0.56) | ADRA2AADRA1ACYP2D6ADRB2ADRB1 | |
| Bromide SCHEMBL11161533 | 0.77 | CASR (0.49) | HIF1ACHRNA7 | |
| Bromide SCHEMBL11178834 | 0.77 | HIF1A (0.47) | MEN1MAPK1KMT2AHTTHIF1A | |
| SCHEMBL19121206 | 0.77 | CYP2D6 (0.51) | ADRA2AADRA1ACYP2D6ADRB2ADRB1 | |
| SCHEMBL11253139 | 0.76 | ADRA1A (0.57) | ADRA2AADRA1ACYP2D6ADRB2ADRB1 | |
| SCHEMBL11274183 | 0.76 | CYP2D6 (0.54) | ADRA2AADRA1ACYP2D6ADRB2ADRB1 | |
| SCHEMBL20350303 | 0.75 | CYP2D6 (0.50) | ADRA2AADRA1ACYP2D6ADRB2ADRB1 | |
| SCHEMBL19121531 | 0.75 | CYP2D6 (0.50) | ADRA2AADRA1ACYP2D6ADRB2ADRB1 | |
| SCHEMBL11264165 | 0.75 | CYP2D6 (0.43) | ADRA2AADRA1ACYP2D6ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009386-B1 | 2,10-DISUBSTITUTED DIBENZO(B,D)PYRANS AND BENZO(C)QUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4206225-A | ANALGESICS | PFIZER INC. (US) | 1980-06-03 | — | — | US | disclosed |
| EP-0009386-A1 | 2,10-Disubstituted dibenzo(b,d)pyrans and benzo(c)quinolines and pharmaceutical compositions thereof | PFIZER INC. (US) | 1980-04-02 | — | — | EP | disclosed |