Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11262193 | 0.86 | CYP2D6 (0.44) | ALDH1A1MEN1KMT2ACYP2D6ADRA2A | |
| SCHEMBL8099078 | 0.82 | MEN1 (0.49) | POLBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11261055 | 0.81 | ALDH1A1 (0.46) | POLBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL15130999 | 0.80 | SIGMAR1 (0.57) | POLBALDH1A1SMN1; SMN2CYP2D6SIGMAR1 | |
| SCHEMBL11363489 | 0.78 | CYP2D6 (0.50) | SMN1; SMN2MEN1KMT2ACYP2D6ADRA2A | |
| Bromide SCHEMBL11264168 | 0.78 | ADRA2A (0.49) | ALDH1A1MEN1KMT2ACYP2D6ADRA2A | |
| SCHEMBL19389253 | 0.77 | CYP2D6 (0.56) | ALDH1A1SMN1; SMN2MEN1KMT2ACYP2D6 | |
| SCHEMBL11165147 | 0.77 | CASR (0.56) | SIGMAR1 | |
| SCHEMBL11186337 | 0.77 | SIGMAR1 (0.46) | POLBALDH1A1KMT2ASIGMAR1HTR2A | |
| SCHEMBL11253139 | 0.76 | ADRA1A (0.57) | MEN1KMT2ACYP2D6ADRA2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009386-B1 | 2,10-DISUBSTITUTED DIBENZO(B,D)PYRANS AND BENZO(C)QUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4206225-A | ANALGESICS | PFIZER INC. (US) | 1980-06-03 | — | — | US | disclosed |
| EP-0009386-A1 | 2,10-Disubstituted dibenzo(b,d)pyrans and benzo(c)quinolines and pharmaceutical compositions thereof | PFIZER INC. (US) | 1980-04-02 | — | — | EP | disclosed |