Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19454785 | 0.86 | TDP1 (0.61) | MAPTTDP1RAB9AKMT2AMEN1 | |
| SCHEMBL11328978 | 0.80 | ADORA1 (0.51) | MAPTRAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11126066 | 0.79 | MAPT (0.61) | MAPTTDP1RAB9AKMT2AMEN1 | |
| SCHEMBL19717504 | 0.78 | TDP1 (0.71) | MAPTTDP1RAB9AKMT2AMEN1 | |
| SCHEMBL12015941 | 0.77 | MAPT (0.51) | MAPTRAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13381021 | 0.73 | MAPT (0.79) | MAPTTDP1RAB9AKMT2AMEN1 | |
| SCHEMBL11537180 | 0.73 | MAPT (0.48) | MAPTTDP1RAB9AKMT2AMEN1 | |
| SCHEMBL11275588 | 0.73 | MAPT (0.46) | MAPTTDP1RAB9AKMT2AMEN1 | |
| SCHEMBL21938127 | 0.73 | GABRA1 (0.54) | MAPTRAB9AKMT2AMEN1KDM4E | |
| SCHEMBL11340503 | 0.72 | ALDH1A1 (0.49) | MAPTRAB9AKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4310551-A | Pharmacologically active substituted 1,2,4-triazines | DIAMOND SHAMROCK CORPORATION (US) | 1982-01-12 | — | — | US | claimed |
| US-4251527-A | ANTIINFLAMMATORY AGENTS | DIAMOND SHAMROCK CORPORATION (US) | 1981-02-17 | — | — | US | claimed |
| US-4157392-A | HYPOTENSIVE AGENTS, ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS AND NERVOUS SYSTEM EFFECTS | DIAMOND SHAMROCK CORPORATION (US) | 1979-06-05 | — | — | US | claimed |
| US-11498936-B2 | Preparation of metal-pyridine derivative complexes for use in medical imaging | UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE (GB) | 2022-11-15 | — | — | US | disclosed |
| US-20200369698-A1 | Preparation of Metal-Pyridine Derivative Complexes for Use in Medical Imaging | UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE (GB) | 2020-11-26 | — | — | US | disclosed |
| US-4310551-A | Pharmacologically active substituted 1,2,4-triazines | DIAMOND SHAMROCK CORPORATION (US) | 1982-01-12 | — | — | US | disclosed |
| US-4251527-A | ANTIINFLAMMATORY AGENTS | DIAMOND SHAMROCK CORPORATION (US) | 1981-02-17 | — | — | US | disclosed |
| US-4157392-A | HYPOTENSIVE AGENTS, ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS AND NERVOUS SYSTEM EFFECTS | DIAMOND SHAMROCK CORPORATION (US) | 1979-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11498936-B2 | Preparation of metal-pyridine derivative complexes for use in medical imaging | MEN1, PDCD1, PDCD1LG2 | MAPT 3497/4885TDP1 3386/4885RAB9A 2846/4885 |
| US-20200369698-A1 | Preparation of Metal-Pyridine Derivative Complexes for Use in Medical Imaging | MEN1, PDCD1, PDCD1LG2 | MAPT 3497/4885TDP1 3386/4885RAB9A 2846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.