Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11264207 | 1.00 | DRD2 (0.44) | DRD2DRD1DRD3LMNAMEN1 | |
| SCHEMBL26616920 | 0.87 | DRD2 (0.44) | DRD2DRD1DRD3LMNAMEN1 | |
| SCHEMBL17538370 | 0.78 | DRD2 (0.51) | DRD2DRD1DRD3LMNAMEN1 | |
| SCHEMBL11088237 | 0.78 | CYP3A4 (0.39) | DRD2DRD1CYP3A4MAPT | |
| SCHEMBL11088225 | 0.78 | CYP3A4 (0.39) | DRD2DRD1CYP3A4MAPT | |
| SCHEMBL10839126 | 0.78 | DRD2 (0.40) | DRD2DRD1DRD3LMNAMEN1 | |
| SCHEMBL11075113 | 0.77 | L3MBTL3 (0.40) | DRD2LMNACYP3A4MAPT | |
| SCHEMBL11075108 | 0.77 | L3MBTL3 (0.40) | DRD2LMNACYP3A4MAPT | |
| SCHEMBL10839988 | 0.75 | SLC18A3 (0.36) | DRD2 | |
| SCHEMBL9824261 | 0.75 | SLC18A3 (0.36) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4311844-A | Octahydro-2H-pyrrolo[3,4,-g]quinolines | ELI LILLY AND COMPANY (US) | 1982-01-19 | — | — | US | disclosed |
| US-4282362-A | TREATING PARKINSON'S DISEASE, INHIBITORS OF PRE ACTIN SECRETION, DOPAMINE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1981-08-04 | — | — | US | disclosed |
| US-4235909-A | DOPAMINE ANTAGONISTS, IN THE TREATMENT OF PARKINSON'S DISEASE | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| EP-0013788-A1 | Octahydro-2H-pyrrolo(3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |