Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 14/20 | 0.36 |
| ▸ | DRD2 | P14416 | 12/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10839988 | 1.00 | SLC18A3 (0.36) | SLC18A3SIGMAR1HTR1ADRD2PRCP | |
| SCHEMBL7986246 | 0.79 | PRCP (0.44) | HTR1ADRD2PRCP | |
| SCHEMBL10919279 | 0.78 | HTR1A (0.32) | SLC18A3SIGMAR1HTR1ADRD2PRCP | |
| SCHEMBL28236427 | 0.78 | PRCP (0.43) | HTR1ADRD2PRCP | |
| SCHEMBL11264207 | 0.75 | DRD2 (0.44) | DRD2 | |
| SCHEMBL11264210 | 0.75 | DRD2 (0.44) | DRD2 | |
| SCHEMBL5580304 | 0.74 | HTR1A (0.44) | HTR1ADRD2PRCP | |
| SCHEMBL31247515 | 0.72 | HTR1A (0.48) | HTR1ADRD2PRCP | |
| SCHEMBL4551362 | 0.71 | — | — | |
| SCHEMBL11015522 | 0.70 | SIGMAR1 (0.53) | SLC18A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0160502-B1 | Improvements in and relating to octahydrothiazolo[4,5-g]quinolines | ELI LILLY AND COMPANY (US) | 1991-09-25 | — | — | EP | disclosed |
| US-4626591-A | Trans-dl-1-alkyl-6-alkoxy-1,2,3,4,4a,5,8,8a octa-hydroquinolines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| EP-0194113-A2 | Process for preparing cis N-alkylperhydroquinolines | ELI LILLY AND COMPANY (US) | 1986-09-10 | — | — | EP | disclosed |
| US-4595754-A | Process for preparing cis N-alkylperhydroquinolines | ELI LILLY AND COMPANY (US) | 1986-06-17 | — | — | US | disclosed |
| EP-0160502-A2 | Improvements in and relating to octahydrothiazolo[4,5-g]quinolines | ELI LILLY AND COMPANY (US) | 1985-11-06 | — | — | EP | disclosed |
| US-4540787-A | Method of preparing trans-D1-1-alkyl-6-oxodecahydroquinolines | ELI LILLY AND COMPANY (US) | 1985-09-10 | — | — | US | disclosed |
| US-4537964-A | Method of preparing permissibly-substituted 1H(and 2H)pyrazolo[3,4-g]quinolines; pyrimido[4,5,g]quinolines; thiazolo[4,5,g]quinolines and intermediates therefore | ELI LILLY AND COMPANY (US) | 1985-08-27 | — | — | US | disclosed |
| US-4537893-A | TREATMENT OF PARKINSONS DISEASE, SEXUAL DYFUNCTION, ANXIETY, DEPRESSION OR HYPERTENSION | ELI LILLY AND COMPANY (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0013787-B1 | OCTAHYDRO PYRAZOLO (3,4-G)QUINOLINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1984-05-02 | — | — | EP | disclosed |
| US-4367231-A | PARKINSON*S SYNDROME | ELI LILLY AND COMPANY (US) | 1983-01-04 | — | — | US | disclosed |
| US-4230861-A | DOPAMINE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1980-10-28 | — | — | US | disclosed |
| US-4198415-A | Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines | ELI LILLY AND COMPANY (US) | 1980-04-15 | — | — | US | disclosed |