Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 11/20 | 0.55 |
| ▸ | DRD3 | P35462 | 11/20 | 0.55 |
| ▸ | DRD4 | P21917 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11272576 | 0.86 | DRD2 (0.56) | HTR1AFYNDRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL11332770 | 0.84 | HTR1A (0.59) | HTR1AFYNDRD2DRD3DRD4 | |
| SCHEMBL11267287 | 0.79 | HTR1A (0.64) | HTR1AFYNDRD2DRD3DRD4 | |
| SCHEMBL11273451 | 0.78 | DRD2 (0.53) | HTR1ADRD2DRD3DRD4 | |
| SCHEMBL11490463 | 0.77 | DRD2 (0.41) | HTR1AFYNDRD2DRD3DRD4 | |
| SCHEMBL9359278 | 0.77 | HTR1A (1.00) | HTR1ADRD2DRD3DRD4MEN1 | |
| Maleic Acid SCHEMBL11281622 | 0.76 | ALDH1A1 (0.41) | HTR1AFYNDRD2DRD3DRD4 | |
| SCHEMBL8486515 | 0.75 | FYN (0.74) | HTR1AFYNDRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL29064041 | 0.75 | HTR1A (0.97) | HTR1ADRD2DRD3DRD4MEN1 | |
| SCHEMBL10606282 | 0.74 | FYN (1.00) | HTR1AFYNDRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0014792-B1 | TETRAHYDRO-2H-BENZO(C)PYRROLES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE COMPOUNDS FOR USE AS THERAPEUTICALS | ELI LILLY AND COMPANY (US) | 1982-12-01 | — | — | EP | claimed |
| EP-0014792-B1 | TETRAHYDRO-2H-BENZO(C)PYRROLES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE COMPOUNDS FOR USE AS THERAPEUTICALS | ELI LILLY AND COMPANY (US) | 1982-12-01 | — | — | EP | disclosed |
| US-4264622-A | TREATMENT OF PARKINSON*S DISEASE | ELI LILLY AND COMPANY (US) | 1981-04-28 | — | — | US | disclosed |
| US-4235776-A | USED FOR TREATMENT OF PARKINSON'S DISEASE, PROLACTIN INHIBITORS, AND DOPAMINE AGONISTS | ELI LILLY AND COMPANY (US) | 1980-11-25 | — | — | US | disclosed |
| EP-0014792-A1 | Tetrahydro-2H-benzo(c)pyrroles, their preparation, pharmaceutical compositions containing them and the compounds for use as therapeuticals | ELI LILLY AND COMPANY (US) | 1980-09-03 | — | — | EP | disclosed |