SCHEMBL11265174

SCHEMBL11265174

O=C1CCCCc2cnccc21

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.57
MAOA P21397 4/20 0.48
MAOB P27338 4/20 0.48
CYP2A6 P11509 1/20 0.48
PRKCI P41743 1/20 0.43
CYP11B1 P15538 2/20 0.42
CYP11B2 P19099 2/20 0.42
CYP1A2 P05177 1/20 0.42
PKN1 Q16512 1/20 0.39
PKN2 Q16513 1/20 0.39
HSD17B1 P14061 1/20 0.39
CHRNB2 P17787 1/20 0.38
CHRNA4 P43681 1/20 0.38
CDC25B P30305 1/20 0.38
ROCK2 O75116 1/20 0.37
GRK2 P25098 1/20 0.37
CHRM2 P08172 1/20 0.37
CHRM4 P08173 1/20 0.37
CHRM3 P20309 1/20 0.37
GRM5 P41594 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2877256 0.96 MAOA (0.53) SIGMAR1MAOAMAOBCYP2A6PRKCI
SCHEMBL31128508 0.96 MAOA (0.53) SIGMAR1MAOAMAOBCYP2A6PRKCI
Hydrochloric Acid SCHEMBL2883050 0.94 MAOA (0.52) SIGMAR1MAOAMAOBCYP2A6PRKCI
SCHEMBL4323285 0.88 CYP1A2 (0.53) SIGMAR1MAOAMAOBCYP2A6CYP11B1
SCHEMBL29792666 0.88 CYP1A2 (0.53) SIGMAR1MAOAMAOBCYP2A6CYP11B1
SCHEMBL8123725 0.84 SIGMAR1 (0.57) SIGMAR1MAOAMAOBCYP2A6PRKCI
SCHEMBL3599167 0.80 MAOA (0.53) SIGMAR1MAOAMAOBCYP2A6PRKCI
SCHEMBL29649256 0.80 MAOA (0.53) SIGMAR1MAOAMAOBCYP2A6PRKCI
Hydrochloric Acid SCHEMBL7258529 0.78 MAOA (0.52) SIGMAR1MAOAMAOBCYP2A6PRKCI
SCHEMBL12524319 0.76 SIGMAR1 (0.95) SIGMAR1CYP11B1CYP11B2CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0003532-B1 OMEGA-(2-(N-LOWER ALKYL-BENZAMIDO)-PHENYL)-ALKANOIC ACIDS, THEIR USE AND PREPARATION, AND MEDICAMENTS CONTAINING THEM Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1982-04-28 EP disclosed
US-4322439-A ω-[2-(N-Lower alkyl-benzamido)-phenyl]-alkanoic acids, their use, and medicaments containing them BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1982-03-30 US disclosed
WO-1979000586-A1 W-(2-N-LOWER ALKYL-BENZAMIDO)-PHENYL)-ALKANOIC ACIDS,THEIR USE AND PREPARATION,AND MEDICAMENTS CONTAINING THEM BYK GULDEN LOMBERG CHEM FAB (DE) 1979-08-23 WO disclosed
EP-0003532-A1 Omega-(2-(N-lower alkyl-benzamido)-phenyl)-alkanoic acids, their use and preparation, and medicaments containing them Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1979-08-22 EP disclosed