Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.64 |
| ▸ | GPR132 | Q9UNW8 | 5/20 | 0.56 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.53 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.53 |
| ▸ | CTSB | P07858 | 2/20 | 0.53 |
| ▸ | CTSS | P25774 | 2/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.53 |
| ▸ | ECE1 | P42892 | 1/20 | 0.52 |
| ▸ | CTSV | O60911 | 1/20 | 0.52 |
| ▸ | CTRC | Q99895 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1792834 | 0.87 | ACE (0.75) | ACECTSLCTSSCTSKACE2 | |
| SCHEMBL11125543 | 0.87 | ACE (0.75) | ACECTSLCTSSCTSKACE2 | |
| SCHEMBL11125540 | 0.87 | ACE (0.75) | ACECTSLCTSSCTSKACE2 | |
| SCHEMBL10659411 | 0.86 | GPR132 (0.72) | ACEGPR132CMKLR2CMKLR1CTSL | |
| SCHEMBL202770 | 0.82 | CTSL (0.60) | ACEGPR132CMKLR2CMKLR1CTSL | |
| SCHEMBL27547470 | 0.82 | CTSL (0.60) | ACEGPR132CMKLR2CMKLR1CTSL | |
| SCHEMBL7894291 | 0.81 | GPR132 (0.60) | ACEGPR132CMKLR2CMKLR1CTSL | |
| SCHEMBL11122993 | 0.80 | ACE (0.64) | ACECTSLCTSSCTSKACE2 | |
| SCHEMBL11122996 | 0.80 | ACE (0.64) | ACECTSLCTSSCTSKACE2 | |
| SCHEMBL11281803 | 0.79 | ACE (1.00) | ACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329473-A | HYPOTENSIVE AGENTS | SRI INTERNATIONAL | 1982-05-11 | — | — | US | disclosed |