Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 12/20 | 0.72 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.68 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.68 |
| ▸ | ACE | P12821 | 3/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | ECE1 | P42892 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 2/20 | 0.57 |
| ▸ | CTSB | P07858 | 2/20 | 0.57 |
| ▸ | CTSS | P25774 | 2/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.57 |
| ▸ | CTSK | P43235 | 1/20 | 0.57 |
| ▸ | CTSV | O60911 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30037998 | 0.92 | GPR132 (0.69) | GPR132CMKLR2CMKLR1ACEPTPN1 | |
| SCHEMBL2229201 | 0.92 | GPR132 (0.69) | GPR132CMKLR2CMKLR1ACEPTPN1 | |
| SCHEMBL3497405 | 0.92 | GPR132 (0.69) | GPR132CMKLR2CMKLR1ACEPTPN1 | |
| SCHEMBL27547470 | 0.88 | CTSL (0.60) | GPR132CMKLR2CMKLR1ACEECE1 | |
| SCHEMBL202770 | 0.88 | CTSL (0.60) | GPR132CMKLR2CMKLR1ACEECE1 | |
| SCHEMBL7894291 | 0.87 | GPR132 (0.60) | GPR132CMKLR2CMKLR1ACEECE1 | |
| SCHEMBL10118977 | 0.86 | CTSL (0.58) | GPR132CMKLR2CMKLR1ACEECE1 | |
| SCHEMBL11265259 | 0.86 | ACE (0.64) | GPR132CMKLR2CMKLR1ACEECE1 | |
| SCHEMBL528464 | 0.85 | ACE (0.76) | GPR132ACEPTPN1CTSLCTSS | |
| SCHEMBL111235 | 0.85 | ACE (0.76) | GPR132ACEPTPN1CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4742067-A | Acylalkylaminocarbonyl substituted amino and imino acid compounds | E. R. SQUIBB & SONS, INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4736066-A | Intermediate for substituted peptide compounds | E. R. SQUIBB & SONS, INC. (US) | 1988-04-05 | — | — | US | disclosed |
| US-4621092-A | HYPOTENSIVE, ANALGESIC | E. R. SQUIBB & SONS, INC. (US) | 1986-11-04 | — | — | US | disclosed |
| US-4604402-A | HYPOTENSIVE AGNETS | E. R. SQUIBB & SONS, INC. (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0159156-A1 | Hydroxy substituted ureido amino and imino acids | E.R. Squibb & Sons, Inc. (US) | 1985-10-23 | — | — | EP | disclosed |
| US-4535176-A | HYPOTENSIVE AGENTS, ANALGESICS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1985-08-13 | — | — | US | disclosed |
| US-4470973-A | HYPOTENSIVE AGENTS, ANALGESICS | E. R. SQUIBB & SONS, INC. (US) | 1984-09-11 | — | — | US | disclosed |
| EP-0103496-A1 | Acylalkylaminocarbonyl substituted amino and imino acid compounds | E.R. Squibb & Sons, Inc. (US) | 1984-03-21 | — | — | EP | disclosed |