Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 3/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL50998 | 0.87 | TSHR (0.43) | EPHX1MEN1KMT2ACHRM2KDM1A | |
| SCHEMBL7951294 | 0.87 | TSHR (0.43) | EPHX1MEN1KMT2ACHRM2KDM1A | |
| SCHEMBL9132881 | 0.79 | SLC5A2 (0.36) | MEN1KMT2ASLC5A2SMN1; SMN2 | |
| SCHEMBL9133282 | 0.78 | FTO (0.43) | KDM1AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL9132397 | 0.78 | TP53 (0.41) | MEN1TP53HPGDKMT2ASLC5A2 | |
| SCHEMBL1499513 | 0.77 | ALDH1A1 (0.47) | EPHX1MEN1TP53CYP1A2CYP2C9 | |
| SCHEMBL27325 | 0.77 | CHRM2 (0.49) | HPGDCHRM2MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL15058077 | 0.76 | EPHX1 (0.56) | EPHX1MEN1TP53CYP1A2CYP2C9 | |
| SCHEMBL3805787 | 0.76 | HPGD (0.43) | EPHX1MEN1TP53CYP1A2CYP2C9 | |
| SCHEMBL9132557 | 0.74 | SLC6A2 (0.42) | MEN1TP53HPGDKMT2ASLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015776-B1 | 1,1'-BIPHENYL-2-YL ALKYLAMINE DERIVATIVES, THEIR PRODUCTION AND CARDIOVASCULAR PREPARATIONS CONTAINING SAME | ELI LILLY AND COMPANY (US) | 1982-06-30 | — | — | EP | disclosed |
| EP-0015776-A1 | 1,1'-Biphenyl-2-yl alkylamine derivatives, their production and cardiovascular preparations containing same | ELI LILLY AND COMPANY (US) | 1980-09-17 | — | — | EP | disclosed |