SCHEMBL11265645

SCHEMBL11265645

COC(=O)CSCc1ccc(Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.61
KMT2A Q03164 5/20 0.61
MEN1 O00255 4/20 0.61
TDP1 Q9NUW8 1/20 0.61
SMN1; SMN2 Q16637 4/20 0.54
LMNA P02545 3/20 0.54
MAPT P10636 4/20 0.53
RAB9A P51151 3/20 0.53
HPGD P15428 2/20 0.53
GAA P10253 2/20 0.53
NPC1 O15118 2/20 0.53
POLB P06746 2/20 0.53
ALOX15 P16050 1/20 0.53
MAPK1 P28482 1/20 0.53
HSD17B10 Q99714 1/20 0.53
CYP1A2 P05177 2/20 0.52
CYP3A4 P08684 2/20 0.52
CYP2C19 P33261 2/20 0.52
XBP1 P17861 1/20 0.50
CYP2D6 P10635 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7018387 0.85 LMNA (0.56) ALDH1A1KMT2AMEN1TDP1SMN1; SMN2
SCHEMBL13870189 0.84 MAPT (0.58) ALDH1A1TDP1SMN1; SMN2MAPTRAB9A
SCHEMBL17785189 0.83 ALDH1A1 (0.64) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL5410393 0.82 GAA (0.61) ALDH1A1KMT2ASMN1; SMN2LMNAMAPT
SCHEMBL560042 0.81 MAPK1 (0.59) ALDH1A1SMN1; SMN2LMNAMAPTRAB9A
SCHEMBL19403377 0.81 PPARG (0.55) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL11713026 0.81 ALDH1A1 (0.58) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL18719809 0.81 KMT2A (0.59) ALDH1A1KMT2AMEN1SMN1; SMN2LMNA
SCHEMBL13778156 0.79 LMNA (0.51) ALDH1A1KMT2AMEN1TDP1SMN1; SMN2
SCHEMBL11464189 0.79 ACE (0.51) LMNAMAPTRAB9AGAAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4325964-A SEDATIVES, MUSCLE RELAXANTS, HYPOTENSIVE AGENTS LABORATOIRE L. LAFON (FR) 1982-04-20 US disclosed
EP-0042054-A1 1-Amino-3-phenyl indoles, their salts and medicaments containing them SIEGFRIED AKTIENGESELLSCHAFT (CH) 1981-12-23 EP disclosed
US-4225617-A PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1980-09-30 US disclosed
US-4209524-A CENTRAL NERVOUS SYSTEM LABORATOIRE L. LAFON (FR) 1980-06-24 US disclosed
US-4209523-A TREATMENT OF THE CENTRAL NERVOUS SYSTEM LABORATOIRE L. LAFON (FR) 1980-06-24 US disclosed
US-4183951-A PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1980-01-15 US disclosed
US-4152458-A CENTRAL NERVOUS SYSTEM, PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1979-05-01 US disclosed
US-4151300-A CENTRAL NERVOUS SYSTEM, PSYCHOTROPIC LABORATOIRE L. LAFON (FR) 1979-04-24 US disclosed
US-4122186-A PSYCHOTROPIC AGENTS LABORATOIRE L. LAFON (FR) 1978-10-24 US disclosed