Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.52 |
| ▸ | BCHE | P06276 | 4/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL749839 | 0.81 | BCHE (0.49) | MCHR1BCHEALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL11148402 | 0.80 | MCHR1 (0.57) | MTNR1AMTNR1BMCHR1BCHECYP1A2 | |
| SCHEMBL15150547 | 0.80 | MOGAT2 (0.49) | MTNR1AMTNR1BBCHEMEN1KMT2A | |
| SCHEMBL11155360 | 0.79 | MCHR1 (0.56) | MTNR1AMTNR1BMCHR1BCHEDRD4 | |
| Hydrochloric Acid SCHEMBL15140753 | 0.79 | MOGAT2 (0.51) | MTNR1AMTNR1BBCHEALDH1A1CYP1A2 | |
| SCHEMBL26871641 | 0.79 | SMN1; SMN2 (0.47) | MCHR1BCHEALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL27686874 | 0.77 | BCHE (0.46) | MCHR1BCHEALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL13452617 | 0.77 | MTNR1A (0.61) | MTNR1AMTNR1BALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL28735087 | 0.77 | SIGMAR1 (0.52) | MTNR1AMTNR1BCYP2D6SIGMAR1 | |
| SCHEMBL2018449 | 0.77 | MEN1 (0.56) | BCHEALDH1A1CYP1A2CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346093-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1982-08-24 | — | — | US | disclosed |
| EP-0014951-A2 | Heterocyclic oxypropanolamine derivatives, process for their preparation and medicines containing these compounds | Roche Diagnostics GmbH (DE) | 1980-09-03 | — | — | EP | disclosed |