SCHEMBL2018449

SCHEMBL2018449

CC(C)CNCc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
ALDH1A1 P00352 3/20 0.56
MAPT P10636 3/20 0.56
TDP1 Q9NUW8 1/20 0.56
CYP1A2 P05177 1/20 0.55
CYP2D6 P10635 1/20 0.55
ANPEP P15144 1/20 0.50
SIGMAR1 Q99720 1/20 0.50
MAOA P21397 1/20 0.50
BCHE P06276 1/20 0.50
OPRM1 P35372 1/20 0.49
OPRK1 P41145 1/20 0.49
ESR1 P03372 1/20 0.49
CHRM2 P08172 1/20 0.48
GAA P10253 1/20 0.48
KDM4E B2RXH2 1/20 0.48
CYP3A4 P08684 1/20 0.48
HTT P42858 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL21879620 0.98 ALDH1A1 (0.58) MEN1KMT2AALDH1A1MAPTTDP1
SCHEMBL16264576 0.86 MEN1 (0.56) MEN1KMT2AALDH1A1MAPTTDP1
SCHEMBL9407510 0.86 MEN1 (0.56) MEN1KMT2AALDH1A1MAPTTDP1
SCHEMBL16439765 0.85 CHRM2 (0.63) MEN1KMT2AALDH1A1MAPTTDP1
SCHEMBL15859356 0.84 CA2 (0.49) MEN1KMT2AALDH1A1MAPTCYP1A2
SCHEMBL8498255 0.83 ALDH1A1 (0.55) ALDH1A1MAPTCYP1A2CYP2D6BCHE
SCHEMBL4530301 0.83 ALDH1A1 (0.77) MEN1KMT2AALDH1A1MAPTTDP1
SCHEMBL13995600 0.83 MEN1 (0.52) MEN1KMT2AALDH1A1MAPTTDP1
SCHEMBL22365200 0.83 MEN1 (0.58) MEN1KMT2AALDH1A1MAPTTDP1
SCHEMBL9034542 0.83 MEN1 (0.52) MEN1KMT2AALDH1A1MAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 297 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119898789-A Flower-like sphere mordenite as well as preparation method and application thereof 中国石油化工股份有限公司 2025-04-29 CN claimed
CN-118620358-A Antifog polyester composite material for packaging film and preparation method thereof 广东宝佳利新材料股份有限公司 2024-09-10 CN claimed
CN-220634309-U Synthesis production line of 4-tert-butyl benzylamine 上海开荣化工科技有限公司 2024-03-22 CN claimed
CN-116396192-A Diurea anti-sagging agent and synthesis method thereof 天津大学 2023-07-07 CN claimed
CN-116063588-A Sagging-resistant resin and preparation method and application thereof 天津大学 2023-05-05 CN claimed
CN-106946828-B Scopolactone phenol ether derivative and its preparation method and application 西南大学 2019-02-26 CN claimed
CN-105130823-B A kind of method of synthesis butenafine 中国科学技术大学 2017-03-01 CN claimed
CN-105130823-A Butenafine synthesis method USTC UNIV SCIENCE TECH CN 2015-12-09 CN claimed
CN-103360314-B The new preparation process of tebufenpyrad JIANG University OF TECHNOLOGY (CN) 2015-08-05 CN claimed
CN-102131815-B Process for the preparation of (3R,3AS,6AR) -hexahydrofuro [2,3-B ] furan-3-yl (1S,2R) -3- [ [ (4-aminophenyl) sulfonyl ] (isobutyl) amino ] -1-benzyl-2-hydroxypropyl carbamate TIBOTEC PHARMACEUTICALS (IE) 2014-10-15 CN claimed
EP-2346877-B1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B]FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL](ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE JANSSEN R & D IRELAND (IE) 2014-08-20 EP claimed
US-8580981-B2 Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate JANSSEN R&D IRELAND (IE) 2013-11-12 US claimed
CN-103360314-A New preparation method of tebufenpyrad UNIV ZHEJIANG TECHNOLOGY 2013-10-23 CN claimed
EP-2346877-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B]FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL](ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE Tibotec Pharmaceuticals (IE) 2011-07-27 EP claimed
CN-102131815-A Process for the preparation of (3R,3AS,6AR) -hexahydrofuro [2,3-B ] furan-3-yl (1S,2R) -3- [ [ (4-aminophenyl) sulfonyl ] (isobutyl) amino ] -1-benzyl-2-hydroxypropyl carbamate TIBOTEC PHARM LTD 2011-07-20 CN claimed
US-20110160468-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE JANSSEN SCIENCES IRELAND UC (IE) 2011-06-30 US claimed
WO-2010023322-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE TIBOTEC PHARMACEUTICALS (IE) 2010-03-04 WO claimed
CN-101462970-A Process for synthesizing chiral methoxybenzylamine PARLING SHANGHAI PHARM TECHNOL (CN) 2009-06-24 CN claimed
US-4954499-A Pyridazinone derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1990-09-04 US claimed
WO-2025243322-A1 A PROCESS FOR PREPARATION OF PRAZIQUANTEL AND INTERMEDIATES THEREFOR ALIVIRA ANIMAL HEALTH LIMITED (IN) 2025-11-27 WO disclosed
US-20250136594-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2025-05-01 US disclosed
CN-119898789-A Flower-like sphere mordenite as well as preparation method and application thereof 中国石油化工股份有限公司 2025-04-29 CN disclosed
CN-119643743-A Method for detecting dimethylketene and application thereof 江苏虹港石化有限公司 2025-03-18 CN disclosed
EP-4469438-A1 COMPOUNDS AND METHODS OF USE Tango Therapeutics, Inc. (US) 2024-12-04 EP disclosed
CN-118620358-A Antifog polyester composite material for packaging film and preparation method thereof 广东宝佳利新材料股份有限公司 2024-09-10 CN disclosed
US-12059420-B2 Inhibitors of indoleamine 2,3-dioxygenase and methods of their use BRISTOL-MYERS SQUIBB COMPANY (US) 2024-08-13 US disclosed
US-12018021-B2 Thiophene derivatives for the treatment of disorders caused by IgE UCB Biopharma SRL (BE) 2024-06-25 US disclosed
CN-220634309-U Synthesis production line of 4-tert-butyl benzylamine 上海开荣化工科技有限公司 2024-03-22 CN disclosed
CN-220634309-U Synthesis production line of 4-tert-butyl benzylamine 上海开荣化工科技有限公司 2024-03-22 CN disclosed
CN-220634309-U Synthesis production line of 4-tert-butyl benzylamine 上海开荣化工科技有限公司 2024-03-22 CN disclosed
CN-113968824-B 2,3, 5-trisubstituted pyrazine compound and preparation method and application thereof 郑州大学 2024-01-19 CN disclosed
WO-2024015262-A1 FUSED RING KRAS INHIBITORS FOR TREATING DISEASE BLOSSOMHILL THERAPEUTICS, INC. (US) 2024-01-18 WO disclosed
EP-3795572-B1 DARUNAVIR PROPIONATE SOLVATE LAURUS LABS LTD (IN) 2023-11-15 EP disclosed
CN-116947645-A Low-carbon environment-friendly method for synthesizing primary amine by taking halohydrocarbon as raw material 徐昌平 2023-10-27 CN disclosed
US-20230312536-A1 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF RAZE THERAPEUTICS, INC. 2023-10-05 US disclosed
CN-111253313-B Method for preparing pyrazole amide compound by utilizing microreactor 青岛恒宁生物科技有限公司 2023-09-26 CN disclosed
US-11739121-B2 EPHA2 agonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-08-29 US disclosed
US-11739121-B2 EPHA2 agonists and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2023-08-29 US disclosed
US-11725010-B2 Polyheterocyclic compounds as METTL3 inhibitors STORM THERAPEUTICS LIMITED (GB) 2023-08-15 US disclosed
US-11725010-B2 Polyheterocyclic compounds as METTL3 inhibitors STORM THERAPEUTICS LIMITED (GB) 2023-08-15 US disclosed
WO-2023146987-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed
WO-2023146987-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed
CN-116396192-A Diurea anti-sagging agent and synthesis method thereof 天津大学 2023-07-07 CN disclosed
CN-116063588-A Sagging-resistant resin and preparation method and application thereof 天津大学 2023-05-05 CN disclosed
CN-116063588-A Sagging-resistant resin and preparation method and application thereof 天津大学 2023-05-05 CN disclosed
US-11634412-B2 3-phosphoglycerate dehydrogenase inhibitors and uses thereof RAZE THERAPEUTICS, INC. (US) 2023-04-25 US disclosed
US-11548870-B2 Compounds useful as inhibitors of helios protein BRISTOL-MYERS SQUIBB COMPANY (US) 2023-01-10 US disclosed
US-20230002378-A1 POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS STORM THERAPEUTICS LIMITED (GB) 2023-01-05 US disclosed
US-20220332709-A1 Thiophene derivatives for the treatment of disorders caused by IgE UCB Biopharma SRL (BE) 2022-10-20 US disclosed
CN-110709471-B Additive manufacturing process using amines for post-curing 科思创德国股份有限公司 2022-04-29 CN disclosed
US-20210299126-A1 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE BRISTOL-MYERS SQUIBB COMPANY 2021-09-30 US disclosed
WO-2021160602-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2021-08-19 WO disclosed
US-20210221843-A1 EPHA2 AGONISTS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2021-07-22 US disclosed
WO-2021142474-A1 COVALENT ORGANIC FRAMEWORKS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-07-15 WO disclosed
WO-2021129629-A1 ZESTE ENHANCER HOMOLOGUE 2 INHIBITOR AND USE THEREOF 四川海思科制药有限公司 2021-07-01 WO disclosed
US-20210147383-A1 COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN BRISTOL-MYERS SQUIBB COMPANY 2021-05-20 US disclosed
CN-112566910-A Thiophene derivatives for the treatment of IgE induced diseases UCB生物制药有限责任公司 2021-03-26 CN disclosed
EP-3795572-A1 DARUNAVIR PROPIONATE SOLVATE Laurus Labs Limited (IN) 2021-03-24 EP disclosed
US-20210053997-A1 TRNA SYNTHETASE INHIBITORS PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2021-02-25 US disclosed
US-10889550-B2 Contrast agents for myocardial perfusion imaging LANTHEUS MEDICAL IMAGING, INC. (US) 2021-01-12 US disclosed
EP-3096751-B1 12-EPI-PLEUROMUTILINS Nabriva Therapeutics GmbH (AT) 2021-01-06 EP disclosed
US-20200370204-A1 PROPERTY MODULATION WITH CHEMICAL TRANSFORMATIONS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2020-11-26 US disclosed
EP-2877474-B1 A PROCESS FOR PREPARATION OF DARUNAVIR LAURUS LABS LTD (IN) 2020-11-04 EP disclosed
WO-2020132566-A1 STING PYRAZOLE AGONISTS AND USES THEREOF NIMBUS TITAN, INC. (US) 2020-06-25 WO disclosed
US-10654832-B2 3-(benzoimidazol-2-YL)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof SAMUMED, LLC (US) 2020-05-19 US disclosed
CN-110799566-A Additive manufacturing method using thermoplastic free-radically crosslinkable building materials 科思创德国股份有限公司 2020-02-14 CN disclosed
WO-2020023355-A1 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE BRISTOL-MYERS SQUIBB COMPANY (US) 2020-01-30 WO disclosed
US-10544157-B2 Process for preparation of Darunavir LAURUS LABS LIMITED (IN) 2020-01-28 US disclosed
CN-110709471-A Additive manufacturing process using amines for post-curing 科思创德国股份有限公司 2020-01-17 CN disclosed
US-20190352279-A1 3-(BENZOIMIDAZOL-2-YL)-INDAZOLE INHIBITORS OF THE WNT SIGNALING PATHWAY AND THERAPEUTIC USES THEREOF VICKERS-SPLICE CO-INVESTMENT LLC (KY) 2019-11-21 US disclosed
CN-110093061-A A kind of photosensitive resin and the preparation method and application thereof with maleimide structure 浙江永太新材料有限公司 2019-08-06 CN disclosed
US-10294218-B2 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity VIROSTATICS SRL (IT) 2019-05-21 US disclosed
US-20190144461-A1 PROCESS FOR PREPARATION OF DARUNAVIR LAURUS LABS LIMITED (IN) 2019-05-16 US disclosed
US-20190127333-A1 CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING LANTHEUS MEDICAL IMAGING, INC. (US) 2019-05-02 US disclosed
CN-106946828-B Scopolactone phenol ether derivative and its preparation method and application 西南大学 2019-02-26 CN disclosed
CN-109314327-A The manufacturing method of conductive material, connection structural bodies and connection structural bodies 积水化学工业株式会社 2019-02-05 CN disclosed
CN-109313956-A The manufacturing method of conductive material, connection structural bodies and connection structural bodies 积水化学工业株式会社 2019-02-05 CN disclosed
US-10183929-B2 3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof SAMUMED, LLC (US) 2019-01-22 US disclosed
EP-3019488-B1 IDO INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2018-11-07 EP disclosed
US-10005768-B2 Carboxamide derivatives and use thereof PURDUE PHARMA L.P. (US) 2018-06-26 US disclosed
US-10005768-B2 Carboxamide derivatives and use thereof PURDUE PHARMA L.P. (US) 2018-06-26 US disclosed
US-20180162840-A1 3-(BENZOIMIDAZOL-2-YL)-INDAZOLE INHIBITORS OF THE WNT SIGNALING PATHWAY AND THERAPEUTIC USES THEREOF VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) 2018-06-14 US disclosed
US-20180162840-A1 3-(BENZOIMIDAZOL-2-YL)-INDAZOLE INHIBITORS OF THE WNT SIGNALING PATHWAY AND THERAPEUTIC USES THEREOF VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) 2018-06-14 US disclosed
US-9951065-B2 Benzimidazole and imadazopyridine carboximidamide compounds GILEAD SCIENCES, INC. (US) 2018-04-24 US disclosed
US-9908867-B2 3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof SAMUMED, LLC (US) 2018-03-06 US disclosed
US-9908867-B2 3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof SAMUMED, LLC (US) 2018-03-06 US disclosed
US-9895330-B2 IDO inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2018-02-20 US disclosed
US-9895330-B2 IDO inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2018-02-20 US disclosed
US-9718774-B2 Indole carboxamide derivatives as P2X7 receptor antagonist IDORSIA PHARMACEUTICALS LTD (CH) 2017-08-01 US disclosed
US-20170204084-A1 NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVE ANTI-HIV ACTIVITY VIROSTATICS SRL (IT) 2017-07-20 US disclosed
US-20170204084-A1 NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVE ANTI-HIV ACTIVITY VIROSTATICS SRL (IT) 2017-07-20 US disclosed
US-9701628-B2 12-epi pleuromutilins NABRIVA THERAPEUTICS AG (AT) 2017-07-11 US disclosed
US-9701628-B2 12-epi pleuromutilins NABRIVA THERAPEUTICS AG (AT) 2017-07-11 US disclosed
US-9676747-B2 Hepatitis B antiviral agents NOVIRA THERAPEUTICS, INC. (US) 2017-06-13 US disclosed
US-9617225-B2 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity VIROSTATICS SRL (IT) 2017-04-11 US disclosed
US-9617225-B2 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity VIROSTATICS SRL (IT) 2017-04-11 US disclosed
US-20170096421-A1 Carboxamide Derivatives and Use Thereof PURDUE PHARMA L.P. 2017-04-06 US disclosed
US-20170096421-A1 Carboxamide Derivatives and Use Thereof PURDUE PHARMA L.P. 2017-04-06 US disclosed
CN-105130823-B A kind of method of synthesis butenafine 中国科学技术大学 2017-03-01 CN disclosed
WO-2017027684-A1 FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME ZAFGEN, INC. (US) 2017-02-16 WO disclosed
CN-104926665-B Method for synthesizing cinacalcet 中国科学技术大学 2017-01-11 CN disclosed
CN-104812749-B Indolecarboxamide derivant as P2X7 receptor antagonist 埃科特莱茵药品有限公司 2016-12-14 CN disclosed
US-20160355525-A1 PROCESS FOR PREPARATION OF DARUNAVIR LAURUS LABS LIMITED (IN) 2016-12-08 US disclosed
US-20160355525-A1 PROCESS FOR PREPARATION OF DARUNAVIR LAURUS LABS LIMITED (IN) 2016-12-08 US disclosed
US-20160355525-A1 PROCESS FOR PREPARATION OF DARUNAVIR LAURUS LABS LIMITED (IN) 2016-12-08 US disclosed
EP-2931717-B1 INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2016-12-07 EP disclosed
US-20160332963-A1 12-EPI PLEUROMUTILINS Nabriva Therapeutics GmbH (AT) 2016-11-17 US disclosed
US-9493449-B2 Carboxamide derivatives and use thereof PURDUE PHARMA L.P. (US) 2016-11-15 US disclosed
US-9475821-B2 Process for preparation of Darunavir LAURUS LABS PRIVATE LIMITED (IN) 2016-10-25 US disclosed
US-9475821-B2 Process for preparation of Darunavir LAURUS LABS PRIVATE LIMITED (IN) 2016-10-25 US disclosed
US-9475821-B2 Process for preparation of Darunavir LAURUS LABS PRIVATE LIMITED (IN) 2016-10-25 US disclosed
US-9453013-B2 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity CHIESI FARMACEUTICI S.P.A. (IT) 2016-09-27 US disclosed
US-9453013-B2 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity CHIESI FARMACEUTICI S.P.A. (IT) 2016-09-27 US disclosed
CN-103408570-B Containing the benzene-naphthalene diimide derivative of 1,3-bis-sulfur-2-ylide alkene conjugate unit, preparation method and application 中国科学院上海有机化学研究所 2016-06-29 CN disclosed
US-20160143870-A1 IDO INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2016-05-26 US disclosed
US-20160143870-A1 IDO INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2016-05-26 US disclosed
EP-3019488-A1 IDO INHIBITORS Bristol-Myers Squibb Company (US) 2016-05-18 EP disclosed
CN-105517999-A Ido inhibitors BRISTOL MYERS SQUIBB CO 2016-04-20 CN disclosed
US-20160031873-A1 Carboxamide Derivatives and Use Thereof PURDUE PHARMA L.P. 2016-02-04 US disclosed
CN-105198785-A Maleimide compound and preparation and application thereof UNIV ZHEJIANG TECHNOLOGY 2015-12-30 CN disclosed
CN-105130823-A Butenafine synthesis method USTC UNIV SCIENCE TECH CN 2015-12-09 CN disclosed
US-20150322008-A1 INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONIST ACTELION PHARMACEUTICALS LTD (CH) 2015-11-12 US disclosed
CN-104926665-A Method for synthesizing cinacalcet USTC UNIV SCIENCE TECH CN 2015-09-23 CN disclosed
CN-103360314-B The new preparation process of tebufenpyrad JIANG University OF TECHNOLOGY (CN) 2015-08-05 CN disclosed
CN-104812749-A Iindole carboxamide derivatives as p2x7 receptor antagonists ACTELION PHARMACEUTICALS LTD 2015-07-29 CN disclosed
US-20150203506-A1 PROCESS FOR PREPARATION OF DARUNAVIR LAURUS LABS PRIVATE LTD. (IN) 2015-07-23 US disclosed
US-20150203506-A1 PROCESS FOR PREPARATION OF DARUNAVIR LAURUS LABS PRIVATE LTD. (IN) 2015-07-23 US disclosed
US-20150203506-A1 PROCESS FOR PREPARATION OF DARUNAVIR LAURUS LABS PRIVATE LTD. (IN) 2015-07-23 US disclosed
CN-104718234-A Curable composition for electronic component and connection structure SEKISUI CHEMICAL CO LTD 2015-06-17 CN disclosed
EP-2877474-A2 A PROCESS FOR PREPARATION OF DARUNAVIR Laurus Labs Private Limited (IN) 2015-06-03 EP disclosed
US-8980913-B2 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity CHIESI FARMACEUTICI S.P.A. (IT) 2015-03-17 US disclosed
US-8980913-B2 Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity CHIESI FARMACEUTICI S.P.A. (IT) 2015-03-17 US disclosed
CN-104395324-A Imidazo-oxadiazole and imidazo-thiadiazole derivatives ARES TRADING SA 2015-03-04 CN disclosed
US-20150057283-A1 REVERSE-TURN MIMETICS AND METHOD RELATING THERETO CHOONGWAE PHARMA CORPORATION (KR) 2015-02-26 US disclosed
CN-102159207-B Substituted pyrrolidine-2-carboxamides HOFFMANN LA ROCHE 2015-02-04 CN disclosed
WO-2015006520-A1 IDO INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-01-15 WO disclosed
WO-2015006520-A1 IDO INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-01-15 WO disclosed
CN-102131815-B Process for the preparation of (3R,3AS,6AR) -hexahydrofuro [2,3-B ] furan-3-yl (1S,2R) -3- [ [ (4-aminophenyl) sulfonyl ] (isobutyl) amino ] -1-benzyl-2-hydroxypropyl carbamate TIBOTEC PHARMACEUTICALS (IE) 2014-10-15 CN disclosed
EP-2346877-B1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B]FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL](ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE JANSSEN R & D IRELAND (IE) 2014-08-20 EP disclosed
EP-2346877-B1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B]FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL](ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE JANSSEN R & D IRELAND (IE) 2014-08-20 EP disclosed
US-20140194441-A1 3-(BENZOIMIDAZOL-2-YL)-INDAZOLE INHIBITORS OF THE WNT SIGNALING PATHWAY AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2014-07-10 US disclosed
US-20140163066-A1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY CHIESI FARMACEUTICI S.P.A. (IT) 2014-06-12 US disclosed
US-20140163066-A1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY CHIESI FARMACEUTICI S.P.A. (IT) 2014-06-12 US disclosed
US-20140142044-A1 PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE The United States of America, as represented by the Secretary, Department of Health & Human Servic (US) 2014-05-22 US disclosed
US-20140057911-A1 NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVING BOTH AROMATIC AND HALOGENIC SUBSTITUENTS VIROSTATICS SRL (IT) 2014-02-27 US disclosed
WO-2014016660-A2 A PROCESS FOR PREPARATION OF DARUNAVIR LAURUS LABS PRIVATE LIMITED (IN) 2014-01-30 WO disclosed
CN-102753522-B Substituted pyrrolidine-2-carboxamides HOFFMANN LA ROCHE 2013-11-27 CN disclosed
CN-103408570-A Naphthalimide derivant containing 1, 3-dithiol-2-yliden conjugation unit, preparation method and application SHANGHAI INST ORGANIC CHEM 2013-11-27 CN disclosed
US-8580981-B2 Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate JANSSEN R&D IRELAND (IE) 2013-11-12 US disclosed
US-8580981-B2 Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate JANSSEN R&D IRELAND (IE) 2013-11-12 US disclosed
US-8580981-B2 Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate JANSSEN R&D IRELAND (IE) 2013-11-12 US disclosed
CN-103360314-A New preparation method of tebufenpyrad UNIV ZHEJIANG TECHNOLOGY 2013-10-23 CN disclosed
CN-102281864-B Beta-amino ester compounds and uses thereof LIVING PROOF INC 2013-10-16 CN disclosed
CN-101370765-B Method for selectively producing primary amine SUMITOMO CHEMICAL CO 2013-03-13 CN disclosed
WO-2013011485-A1 PROCESS FOR THE PREPARATION OF SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS RANBAXY LABORATORIES LIMITED (IN) 2013-01-24 WO disclosed
US-8334290-B2 CETP inhibitors MERCK SHARP & DOHME CORP. (US) 2012-12-18 US disclosed
US-8334290-B2 CETP inhibitors MERCK SHARP & DOHME CORP. (US) 2012-12-18 US disclosed
US-8299267-B2 (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating COMENTIS, INC. (US) 2012-10-30 US disclosed
CN-102753522-A Substituted pyrrolidine-2-carboxamides HOFFMANN LA ROCHE 2012-10-24 CN disclosed
CN-102666490-A Aminopyridine compound UBE INDUSTRIES 2012-09-12 CN disclosed
CN-101142174-B Novel compound as vanilloid receptor antagonist, isomer thereof or pharmaceutically acceptable salt thereof, and pharmaceutical composition comprising the same AMOREPACIFIC CORP 2012-05-09 CN disclosed
CN-101462970-B Process for synthesizing chiral methoxybenzylamine BAILING PHARMACEUTICAL (SHANGHAI) CO., LTD. (CN) 2012-02-08 CN disclosed
CN-102281864-A Beta-amino ester compounds and uses thereof 2011-12-14 CN disclosed
US-20110257185-A1 REVERSE-TURN MIMETICS AND METHOD RELATING THERETO CHOONGWAE PHARMA CORPORATION (KR) 2011-10-20 US disclosed
EP-2371967-A1 Production of carotenoids in oleaginous yeast and fungi DSM IP Assets B.V. (NL) 2011-10-05 EP disclosed
CN-102159207-A Substituted pyrrolidine-2-carboxamides HOFFMANN LA ROCHE 2011-08-17 CN disclosed
EP-2346877-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B]FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL](ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE Tibotec Pharmaceuticals (IE) 2011-07-27 EP disclosed
CN-102131815-A Process for the preparation of (3R,3AS,6AR) -hexahydrofuro [2,3-B ] furan-3-yl (1S,2R) -3- [ [ (4-aminophenyl) sulfonyl ] (isobutyl) amino ] -1-benzyl-2-hydroxypropyl carbamate TIBOTEC PHARM LTD 2011-07-20 CN disclosed
US-20110160468-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE JANSSEN SCIENCES IRELAND UC (IE) 2011-06-30 US disclosed
US-20110160468-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE JANSSEN SCIENCES IRELAND UC (IE) 2011-06-30 US disclosed
US-20110160468-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE JANSSEN SCIENCES IRELAND UC (IE) 2011-06-30 US disclosed
CN-101333218-B Formamide alkylbenzene substituted mercapto pyrrolidine carbapenem compounds SHANDONG XUANZHU PHARM TECH CO 2011-05-18 CN disclosed
CN-1993323-B Indole, indazole or indoline derivatives HOFFMANN LA ROCHE 2011-04-20 CN disclosed
US-20110015371-A1 Inhibitors of interleukin-1 beta converting enzyme VERTEX PHARMACEUTICALS INCORPORATED (US) 2011-01-20 US disclosed
EP-2267046-A1 Process for homo- or copolymerization of conjugated olefines DOW GLOBAL TECHNOLOGIES INC. (US) 2010-12-29 EP disclosed
US-20100286170-A1 (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING COMENTIS, INC 2010-11-11 US disclosed
US-20100286145-A1 ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY COMENTIS, INC. (US) 2010-11-11 US disclosed
CN-101842356-A Polymorphs of (3- (((4-tert-butylbenzyl) - (pyridine-3-sulfonyl) -amino) -methyl) -phenoxy) -acetic acid sodium salt or hydrate thereof and process for producing the same PFIZER PROD INC 2010-09-22 CN disclosed
CN-101821238-A Suppress the active isophthaloyl sulfonamide derivatives of beta-secretase (BETA-SECRETASE) COMENTIS INC 2010-09-01 CN disclosed
CN-101367819-B 5-substituent-2-(4-substituted phenyl)-6,7-dihydrogen pyrazole-[1,5-a]pyrazine-4(5H)-ketone derivant and uses thereof UNIV SHANDONG 2010-08-18 CN disclosed
EP-2205596-A1 (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING COMENTIS, INC. (US) 2010-07-14 EP disclosed
US-20100144733-A1 Compounds, compositions and methods comprising heteroaromatic derivatives INSTITUTE FOR ONEWORLD HEALTH 2010-06-10 US disclosed
EP-2178837-A2 ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY COMENTIS, INC. (US) 2010-04-28 EP disclosed
CN-101679370-A Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals GRUENENTHAL GMBH 2010-03-24 CN disclosed
WO-2010023322-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE TIBOTEC PHARMACEUTICALS (IE) 2010-03-04 WO disclosed
WO-2010023322-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE TIBOTEC PHARMACEUTICALS (IE) 2010-03-04 WO disclosed
US-20090318429-A1 Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives INSTITUTE FOR ONEWORLD HEALTH 2009-12-24 US disclosed
US-20090264405-A1 Cetp Inhibitors MERCK SHARP & DOHME LLC 2009-10-22 US disclosed
US-20090264405-A1 Cetp Inhibitors MERCK SHARP & DOHME LLC 2009-10-22 US disclosed
CN-100537528-C 4-(methyl sulfonyl amino) phenyl analogues as vanilloid antagonist showing excellent analgesic activity and the pharmaceutical compositions comprising the same GRUENENTHAL GMBH (DE) 2009-09-09 CN disclosed
CN-101462970-A Process for synthesizing chiral methoxybenzylamine PARLING SHANGHAI PHARM TECHNOL (CN) 2009-06-24 CN disclosed
WO-2009042694-A1 (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING COMENTIS, INC. (US) 2009-04-02 WO disclosed
CN-101367819-A 5-substituent-2-(4-substituted phenyl)-6,7-dihydrogen pyrazole-[1,5-a]pyrazine-4(5H)-ketone derivant and uses thereof UNIV SHANDONG (CN) 2009-02-18 CN disclosed
CN-101370765-A Method for selectively producing primary amine SUMITOMO CHEMICAL CO (JP) 2009-02-18 CN disclosed
WO-2009015369-A2 COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2009-01-29 WO disclosed
CN-101333218-A Formamide alkylbenzene substituted mercapto pyrrolidine carbapenem compounds SHANDONG XUANZHU MEDICAL SCI T (CN) 2008-12-31 CN disclosed
US-7462625-B2 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto NEUROCRINE BIOSCIENCES, INC. (US) 2008-12-09 US disclosed
US-20080171756-A1 N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors SMITHKLINE BEECHAM CORPORATION 2008-07-17 US disclosed
US-20080107598-A1 Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications COLIP, GREGORY RUSSELL 2008-05-08 US disclosed
CN-101142174-A Novel compounds as vanilloid receptor antagonists, isomers thereof or pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising the same AMOREPACIFIC CORP (KR) 2008-03-12 CN disclosed
CN-101128421-A Methods and compositions for treating amyloid-related diseases NEUROCHEM INTERNAT LTD (CH) 2008-02-20 CN disclosed
US-20070208049-A1 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto NEUROCRINE BIOSCIENCES, INC. (US) 2007-09-06 US disclosed
CN-1326903-C Hydrophilized blocked polyisocyanates BAYER MATERIALSCIENCE AG (DE) 2007-07-18 CN disclosed
CN-1993323-A Indole, indazole or indoline derivatives HOFFMANN LA ROCHE (CH) 2007-07-04 CN disclosed
CN-1948359-A Reaction system, preparation and application thereof BAYER MATERIALSCIENCE AG (DE) 2007-04-18 CN disclosed
CN-1301981-C Medicinal composition containing 1,3-thiazine derivative SHIONOGI & CO (JP) 2007-02-28 CN disclosed
EP-1438310-B1 BETA-CARBOLIN DERIVATIVES AS PTP-INHIBITORS TRANSTECH PHARMA INC (US) 2006-12-20 EP disclosed
US-20060276518-A1 Aryl and heteroaryl compounds and methods to modulate coagulation TRANSTECH PHARMA, INC. 2006-12-07 US disclosed
CN-1863777-A Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor ABBOTT LAB (US) 2006-11-15 CN disclosed
US-20060247261-A1 Pyrimidine compounds GLAXO GROUP LIMITED (GB) 2006-11-02 US disclosed
CN-1852891-A 4- (methylsulfonylamino) phenyl analogues as vanilloid antagonists with high analgesic activity and pharmaceutical compositions containing them GRUENENTHAL GMBH (DE) 2006-10-25 CN disclosed
US-7122580-B2 Aryl and heteroaryl compounds and methods to modulate coagulation TRANSTECH PHARMA, INC. (US) 2006-10-17 US disclosed
CN-1793121-A Fused salt containing asymmetrical sulfonium cation, its preparation process and application in electrochemical device UNIV SHANGHAI JIAOTONG (CN) 2006-06-28 CN disclosed
CN-1729223-A Hydrophilized blocked polyisocyanates BAYER MATERIALSCIENCE AG (DE) 2006-02-01 CN disclosed
EP-1597292-A2 PROCESS FOR HOMO- OR COPOLYMERIZATION OF CONJUGATED OLEFINES DOW GLOBAL TECHNOLOGIES INC. (US) 2005-11-23 EP disclosed
CN-1662487-A Amide linker peroxisome proliferator-activated receptor modulators LILLY CO ELI (US) 2005-08-31 CN disclosed
US-6933303-B2 Heteroaryl-fused nitrogen heterocycles as therapeutic agents TRANSTECH PHARMA, INC. (US) 2005-08-23 US disclosed
US-20050113576-A1 Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor ABBOTT LABORATORIES 2005-05-26 US disclosed
US-20050096335-A1 Heteroaryl - fused nitrogen heterocycles as therapeutic agents TRANSTECH PHARMA, INC. 2005-05-05 US disclosed
CN-1169795-C Nitrogenous heterocyclic compounds Э�ͷ��͹�ҵ��ʽ���� 2004-10-06 CN disclosed
WO-2004076504-A2 PROCESS FOR HOMO- OR COPOLYMERIZATION OF CONJUGATED OLEFINES DOW GLOBAL TECHNOLOGIES, INC. (US) 2004-09-10 WO disclosed
EP-1438310-A1 BETA-CARBOLIN DERIVATIVES AS PTP-INHIBITORS TransTech Pharma Inc. (US) 2004-07-21 EP disclosed
CN-1514831-A Medicinal composition containing 1,3-thiazine derivative ��Ұ����ҩ��ʽ���� 2004-07-21 CN disclosed
US-20040110832-A1 management, treatment and/or control of diseases caused in intrinsic clotting pathway utilizing factor IX such as stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures etc TRANSTECH PHARMA, LLC 2004-06-10 US disclosed
CN-1138761-C 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives, their preparation and use as dopamine autoreceptor (D2) agonists 2004-02-18 CN disclosed
US-20040014778-A1 Heteroaryl - fused nitrogen heterocycles as therapeutic agents VTVX HOLDINGS I LLC 2004-01-22 US disclosed
CN-1131202-C Calcium receptor-active compounds KIRIN BREWERY (JP) 2003-12-17 CN disclosed
EP-0900211-B1 THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS UPJOHN CO (US) 2003-07-02 EP disclosed
WO-2003033496-A1 BETA-CARBOLIN DERIVATIVES AS PTP-INHIBITORS TRANSTECH PHARMA, INC. (US) 2003-04-24 WO disclosed
CN-1387519-A 2-imino-1, 3-thiazine derivatives SHIONOGI & CO (JP) 2002-12-25 CN disclosed
WO-2002100842-A1 SULFONYLOXAZOLAMINES AND THEIR USE AS 5-HT6 LIGANDS MERCK PATENT GMBH (DE) 2002-12-19 WO disclosed
CN-1072935-C Preparation method for medicinal composition containing aza-steroid compound for treating prostatic hyperplasia SANKYO CO (JP) 2001-10-17 CN disclosed
CN-1308608-A Substituted beta-amino acid inhibitors of methionine aminopeptidase-2 ABBOTT LAB (US) 2001-08-15 CN disclosed
CN-1306011-A Polyaddition catalyst component, polyaddition catalyst and method for preparing addition polymer SUMITOMO CHEMICAL CO (JP) 2001-08-01 CN disclosed
US-6177438-B1 ANALGESICS, DIURETICS, ANTITUSSIVE AGENTS TORAY INDUSTRIES, INC. (JP) 2001-01-23 US disclosed
US-6147084-A Brain cell protective agent TORAY INDUSTRIES, INC. (JP) 2000-11-14 US disclosed
EP-0519353-B1 Indolizin derivatives, process for their preparation and pharmaceutical composition containing them FUJISAWA PHARMACEUTICAL CO (JP) 2000-08-16 EP disclosed
CN-1053672-C Azasteroid compounds for the treatment of prostatic hypertrophy SANKYO CO (JP) 2000-06-21 CN disclosed
CN-1252060-A 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one derivatives, their preparation and use as dopamine autoreceptor (D2) agonists AMERICAN HOME PROD (US) 2000-05-03 CN disclosed
US-5972953-A MORPHINAN DERIVATIVE; USEFAL AS PREVENTIVE AND THERAPUETIC AGENTS OF ISCHEMIC BRAIN DISORDERS, BRAIN NERVE CELL DISORDERS AND DEMENTIA TORAY INDUSTRIES, LTD. (JP) 1999-10-26 US disclosed
CN-1225083-A Calcium receptor-active compounds KIRIN BREWERY (JP) 1999-08-04 CN disclosed
CN-1043992-C Process for preparation of indolizine derivatives FUJISAWA PHARMACEUTICAL CO (JP) 1999-07-07 CN disclosed
EP-0900211-A1 THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-03-10 EP disclosed
CN-1209319-A Preparation method for medicinal composition containing aza-steroid compound for treating prostatic hyperplasia SANKYO CO (JP) 1999-03-03 CN disclosed
CN-1042226-C Heterocyclic derivatives FUJISAWA PHARMACEUTICAL CO (JP) 1999-02-24 CN disclosed
CN-1208404-A Nitrogenous heterocyclic compounds KYOWA HAKKO KOGYO KK (JP) 1999-02-17 CN disclosed
CN-1041095-C Steroid compound and pharmaceutical composition for treating prostatic hypertrophy SANKYO CO (JP) 1998-12-09 CN disclosed
US-5847148-A Thiadiazole derivatives useful for the treatment of diseases related to connective tissue degradation PHARMACIA & UPJOHN COMPANY (US) 1998-12-08 US disclosed
EP-0717742-B1 PROCESS FOR THE PREPARATION OF INDOLIZINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO (JP) 1998-11-11 EP disclosed
EP-0661283-B1 BRAIN CELL PROTECTIVE TORAY INDUSTRIES (JP) 1998-10-21 EP disclosed
CN-1195666-A Intermediates of steroids, their preparation and uses SANKYO CO (JP) 1998-10-14 CN disclosed
US-5780633-A Process for the preparation of indolizine derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-07-14 US disclosed
US-5760025-A ADMINISTERING TESTOSTERONE 5A-REDUCTASE INHIBITORS SANKYO COMPANY, LIMITED (JP) 1998-06-02 US disclosed
US-5717088-A REACTING WITH A CYANOPHOSPHATE IN THE PRESENCE OF AN ALKALI METAL CYANIDE SANKYO COMPANY, LIMITED (JP) 1998-02-10 US disclosed
US-5698720-A INTERMEDIATES FOR TESTOSTERONE 5-ALPHA-REDUCTASE INHIBITORS SANKYO COMPANY, LIMITED (JP) 1997-12-16 US disclosed
EP-0751767-A4 THERAPEUTIC GUANIDINES CAMBRIDGE NEUROSCIENCE INC (US) 1997-12-10 EP disclosed
EP-0804428-A1 BIS-SULFONAMIDE HYDROXYETHYLAMINO RETROVIRAL PROTEASE INHIBITORS G.D. SEARLE & CO. (US) 1997-11-05 EP disclosed
WO-1997040031-A1 THIADIAZOLYL(THIO)UREAS USEFUL AS MATRIX METALLOPROTEASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1997-10-30 WO disclosed
EP-0751767-A1 THERAPEUTIC GUANIDINES CAMBRIDGE NEUROSCIENCE, INC. (US) 1997-01-08 EP disclosed
EP-0736037-A1 NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPARTYL-D-$g(a)-AMINOALKANOYL-(S)-N-$g(a)-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS THE COCA-COLA COMPANY (US) 1996-10-09 EP disclosed
CN-1130907-A Process for preparation of indolizine derivatives FUJISAWA PHARMACEUTICAL CO (JP) 1996-09-11 CN disclosed
US-5536714-A Steroid derivatives for the treatment of prostatic hypertrophy their preparation and uses SANKYO COMPANY, LIMITED (JP) 1996-07-16 US disclosed
EP-0717742-A1 PROCESS FOR THE PREPARATION OF INDOLIZINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-06-26 EP disclosed
EP-0715618-A1 HYDROXYETHYLAMINO SULPHONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS G.D. SEARLE & CO. (US) 1996-06-12 EP disclosed
CN-1030701-C Indole derivatives and process for production thereof FUJISAWA PHARMACEUTICAL CO (JP) 1996-01-17 CN disclosed
EP-0663401-A1 MORPHINAN DERIVATIVE AND MEDICINAL USE TORAY INDUSTRIES, INC. (JP) 1995-07-19 EP disclosed
EP-0661283-A1 BRAIN CELL PROTECTIVE TORAY INDUSTRIES, INC. (JP) 1995-07-05 EP disclosed
WO-1995007279-A2 PROCESS FOR THE PREPARATION OF INDOLIZINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-03-16 WO disclosed
US-5334716-A Preventing testosteron 5a-reductase mediated diseases; alopecia, acne, prostatism FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-08-02 US disclosed
EP-0600084-A1 INDOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-06-08 EP disclosed
US-5312829-A Testosterone 5alpha-reductase inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-17 US disclosed
US-5302621-A Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO COMPANY, LIMITED (JP) 1994-04-12 US disclosed
CN-1083070-A Steroid derivatives for the treatment of prostatic hypertrophy, process for their preparation and their use SANKYO CO (JP) 1994-03-02 CN disclosed
EP-0567271-A2 Steroid derivatives for the treatment of prostatic hypertrophy, their preparation and uses SANKYO COMPANY LIMITED (JP) 1993-10-27 EP disclosed
US-5212320-A Enzyme inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-05-18 US disclosed
WO-1993003012-A1 INDOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-02-18 WO disclosed
CN-1067893-A Hete rocyclic derivatives FUJISAWA PHARMACEUTICAL CO (JP) 1993-01-13 CN disclosed
EP-0519353-A2 Indolizin derivatives, process for their preparation and pharmaceutical composition containing them FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-12-23 EP disclosed
CN-1062145-A Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO CO (JP) 1992-06-24 CN disclosed
EP-0484094-A2 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use Sankyo Company Limited (JP) 1992-05-06 EP disclosed
CN-1015178-B PROCESS AND INTERMEDIATES FOR BETA-LACTAM ANTIBIOTICS HARVARD COLLEGE (US) 1991-12-25 CN disclosed
CN-1015103-B PROCESS FOR PREPARING 3-HALO-1-CARBO-3-CEPHEM-4-CARBOXYLIC ACID AND ITS DERIV. HARVARD COLLEGE (US) 1991-12-18 CN disclosed
CN-1056685-A Indole derivatives and preparation method thereof FUJISAWA PHARMACEUTICAL CO (JP) 1991-12-04 CN disclosed
EP-0458207-A2 Indole derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-11-27 EP disclosed
EP-0212535-B1 N6-DISUBSTITUTED PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM Roche Diagnostics GmbH (DE) 1991-05-29 EP disclosed
US-4954499-A Pyridazinone derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1990-09-04 US disclosed
US-4757050-A Urea, amide group-containing E. R. SQUIBB SONS, INC. (US) 1988-07-12 US disclosed
US-4749792-A Diamino ketones and alcohols as analgesic agents E. R. SQUIBB & SONS, INC. (US) 1988-06-07 US disclosed
CN-86104783-A The method for preparing beta-Lactam antibiotics 1987-02-04 CN disclosed
CN-86105247-A Antibiotic intermediate and preparation method 1987-02-04 CN disclosed
US-4442286-A Preparation of amines by the reduction of imines with phosphorous acid PETROLITE CORPORATION (US) 1984-04-10 US disclosed
US-4352696-A Process and composition THE UPJOHN COMPANY (US) 1982-10-05 US disclosed
EP-0007717-B1 CLAVULANIC ACID DERIVATIVES, A PROCESS FOR THEIR PREPARATION, THEIR USE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BEECHAM GROUP PLC (GB) 1982-08-11 EP disclosed
US-4257995-A STORAGE STABILITY THE UPJOHN COMPANY (US) 1981-03-24 US disclosed
US-4235809-A α-Amino phosphonic acids PETROLITE CORPORATION (US) 1980-11-25 US disclosed
EP-0007717-A1 Clavulanic acid derivatives, a process for their preparation, their use, and pharmaceutical compositions containing them BEECHAM GROUP PLC (GB) 1980-02-06 EP disclosed
US-4182887-A ANTIPHLOGISTIC, ANTITHROMBOTIC BOEHRINGER INGELHEIM GMBH (DE) 1980-01-08 US disclosed
US-4182887-A ANTIPHLOGISTIC, ANTITHROMBOTIC BOEHRINGER INGELHEIM GMBH (DE) 1980-01-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (50 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10294218-B2 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity DUT, UMPS, DPYD MEN1 4820/4885KMT2A 1615/4885ALDH1A1 872/4885
US-20140163066-A1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY ADRB2, ADRB1, ADRA2B MEN1 3333/4885KMT2A 3049/4885ALDH1A1 1182/4885
US-20090264405-A1 Cetp Inhibitors CETP, APOB, PCSK9 MEN1 3792/4885KMT2A 3692/4885ALDH1A1 3312/4885
US-20040110832-A1 management, treatment and/or control of diseases caused in intrinsic clotting pathway utilizing factor IX such as stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures etc TFPI, F9, TFPI2 MEN1 1372/4885KMT2A 3655/4885ALDH1A1 3511/4885
US-20210053997-A1 TRNA SYNTHETASE INHIBITORS TRMT1, AARS1, GARS1 MEN1 3487/4885KMT2A 1187/4885ALDH1A1 2254/4885
US-20190352279-A1 3-(BENZOIMIDAZOL-2-YL)-INDAZOLE INHIBITORS OF THE WNT SIGNALING PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A MEN1 4360/4885KMT2A 4180/4885ALDH1A1 1546/4885
US-20250136594-A1 COMPOUNDS AND METHODS OF USE CNKSR1, UGT1A1, REV1 MEN1 521/4885KMT2A 2276/4885ALDH1A1 29/4885
US-20040014778-A1 Heteroaryl - fused nitrogen heterocycles as therapeutic agents PTPRG, PTPRM, PTPRC MEN1 2485/4885KMT2A 2837/4885ALDH1A1 3422/4885
US-20080171756-A1 N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors HIF1AN, EGLN2, EGLN3 MEN1 2935/4885KMT2A 734/4885ALDH1A1 513/4885
US-20190144461-A1 PROCESS FOR PREPARATION OF DARUNAVIR SAMHD1, CYP3A5, DARS1 MEN1 4858/4885KMT2A 4163/4885ALDH1A1 1810/4885
US-11739121-B2 EPHA2 agonists and uses thereof EPHA2, EPHB2, EPHA6 MEN1 3461/4885KMT2A 1626/4885ALDH1A1 4008/4885
US-20080107598-A1 Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications TNNI3, CAD, TNNT2 MEN1 214/4885KMT2A 1922/4885ALDH1A1 2581/4885
US-11634412-B2 3-phosphoglycerate dehydrogenase inhibitors and uses thereof PHGDH, G6PD, PGD MEN1 3285/4885KMT2A 2306/4885ALDH1A1 222/4885
US-20110160468-A1 PROCESS FOR THE PREPARATION OF (3R,3AS,6AR)-HEXAHYDROFURO [2,3-B] FURAN-3-YL (1S,2R)-3-[[(4-AMINOPHENYL) SULFONYL] (ISOBUTYL) AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE HTR3C, HPD, HAAO MEN1 4859/4885KMT2A 2401/4885ALDH1A1 317/4885
US-20140142044-A1 PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE PLK1, PLK4, PLK3 MEN1 4339/4885KMT2A 2194/4885ALDH1A1 4542/4885
US-10544157-B2 Process for preparation of Darunavir SAMHD1, CYP3A5, DARS1 MEN1 4858/4885KMT2A 4163/4885ALDH1A1 1810/4885
US-20160143870-A1 IDO INHIBITORS IDO1, IDO2, TDO2 MEN1 1664/4885KMT2A 572/4885ALDH1A1 435/4885
US-20060276518-A1 Aryl and heteroaryl compounds and methods to modulate coagulation TFPI, F9, F2 MEN1 3448/4885KMT2A 2112/4885ALDH1A1 2142/4885
US-20050096335-A1 Heteroaryl - fused nitrogen heterocycles as therapeutic agents PTPRG, PTPRM, PTPRC MEN1 2485/4885KMT2A 2837/4885ALDH1A1 3422/4885
US-20150203506-A1 PROCESS FOR PREPARATION OF DARUNAVIR SAMHD1, DARS1, CYP3A43 MEN1 4867/4885KMT2A 4352/4885ALDH1A1 2031/4885
US-20210147383-A1 COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN IKZF2, RPL6, HNRNPR MEN1 1057/4885KMT2A 1467/4885ALDH1A1 3947/4885
US-20210221843-A1 EPHA2 AGONISTS AND USES THEREOF EPHA2, EPHB2, EPHA6 MEN1 3429/4885KMT2A 1673/4885ALDH1A1 3979/4885
US-10005768-B2 Carboxamide derivatives and use thereof TRPV1, CACNA1A, SCN10A MEN1 3470/4885KMT2A 1142/4885ALDH1A1 1621/4885
US-20150057283-A1 REVERSE-TURN MIMETICS AND METHOD RELATING THERETO WNT1, APC, WNT3 MEN1 336/4885KMT2A 4111/4885ALDH1A1 4305/4885
US-20160355525-A1 PROCESS FOR PREPARATION OF DARUNAVIR SAMHD1, CYP3A5, DARS1 MEN1 4858/4885KMT2A 4163/4885ALDH1A1 1810/4885
US-20160031873-A1 Carboxamide Derivatives and Use Thereof TRPV1, CACNA1A, SCN10A MEN1 3687/4885KMT2A 956/4885ALDH1A1 1283/4885
US-20210299126-A1 INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE IDO1, IDO2, INMT MEN1 1036/4885KMT2A 556/4885ALDH1A1 373/4885
US-12059420-B2 Inhibitors of indoleamine 2,3-dioxygenase and methods of their use IDO1, IDO2, INMT MEN1 1036/4885KMT2A 556/4885ALDH1A1 373/4885
US-20050113576-A1 Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor TRPV1, TMEM109, VIPR1 MEN1 4636/4885KMT2A 3095/4885ALDH1A1 298/4885
US-20220332709-A1 Thiophene derivatives for the treatment of disorders caused by IgE TSLP, CYSLTR1, CYSLTR2 MEN1 2963/4885KMT2A 4104/4885ALDH1A1 233/4885
US-20190127333-A1 CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING TNNI3, TNNT2, FABP3 MEN1 154/4885KMT2A 4432/4885ALDH1A1 2228/4885
US-20110257185-A1 REVERSE-TURN MIMETICS AND METHOD RELATING THERETO WNT1, APC, WNT3 MEN1 336/4885KMT2A 4111/4885ALDH1A1 4305/4885
US-20100286145-A1 ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY BACE1, BACE2, APP MEN1 3945/4885KMT2A 1493/4885ALDH1A1 1223/4885
US-20170096421-A1 Carboxamide Derivatives and Use Thereof TRPV1, CACNA1A, SCN10A MEN1 3470/4885KMT2A 1142/4885ALDH1A1 1621/4885
US-20230002378-A1 POLYHETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS METTL3, DIMT1, TPMT MEN1 1213/4885KMT2A 64/4885ALDH1A1 2056/4885
US-20100144733-A1 Compounds, compositions and methods comprising heteroaromatic derivatives CFTR, PKD1, PKD2 MEN1 2895/4885KMT2A 4715/4885ALDH1A1 2115/4885
US-20150322008-A1 INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONIST P2RX3, P2RX7, P2RX1 MEN1 3139/4885KMT2A 1860/4885ALDH1A1 1594/4885
US-20140057911-A1 NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVING BOTH AROMATIC AND HALOGENIC SUBSTITUENTS DPYD, ABL1, BRD4 MEN1 4027/4885KMT2A 219/4885ALDH1A1 507/4885
US-10183929-B2 3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof WNT1, WNT3, WNT3A MEN1 4360/4885KMT2A 4180/4885ALDH1A1 1546/4885
US-20140194441-A1 3-(BENZOIMIDAZOL-2-YL)-INDAZOLE INHIBITORS OF THE WNT SIGNALING PATHWAY AND THERAPEUTIC USES THEREOF WNT1, WNT3, WNT3A MEN1 4360/4885KMT2A 4180/4885ALDH1A1 1546/4885
US-11725010-B2 Polyheterocyclic compounds as METTL3 inhibitors METTL3, DIMT1, TPMT MEN1 1213/4885KMT2A 64/4885ALDH1A1 2056/4885
US-20060247261-A1 Pyrimidine compounds CNR2, CNR1, P2RX5 MEN1 4669/4885KMT2A 2825/4885ALDH1A1 3083/4885
US-12018021-B2 Thiophene derivatives for the treatment of disorders caused by IgE TSLP, CYSLTR1, CYSLTR2 MEN1 2963/4885KMT2A 4104/4885ALDH1A1 233/4885
US-10654832-B2 3-(benzoimidazol-2-YL)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof WNT1, WNT3, WNT3A MEN1 4360/4885KMT2A 4180/4885ALDH1A1 1546/4885
US-20230312536-A1 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF PHGDH, G6PD, PGD MEN1 3285/4885KMT2A 2306/4885ALDH1A1 222/4885
US-20160332963-A1 12-EPI PLEUROMUTILINS MLN, TCF12, PLEC MEN1 811/4885KMT2A 1237/4885ALDH1A1 543/4885
US-20100286170-A1 (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING BACE1, BACE2, PSEN1 MEN1 4473/4885KMT2A 2623/4885ALDH1A1 1430/4885
US-10889550-B2 Contrast agents for myocardial perfusion imaging TNNI3, TNNT2, FABP3 MEN1 154/4885KMT2A 4432/4885ALDH1A1 2228/4885
US-20110015371-A1 Inhibitors of interleukin-1 beta converting enzyme IL1B, IL1A, IL1R1 MEN1 1388/4885KMT2A 4426/4885ALDH1A1 269/4885
US-20090318429-A1 Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives CFTR, PKD1, PKD2 MEN1 2895/4885KMT2A 4715/4885ALDH1A1 2115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.