Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 7/20 | 0.74 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.74 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | RXRG | P48443 | 7/20 | 0.41 |
| ▸ | RXRA | P19793 | 6/20 | 0.41 |
| ▸ | RXRB | P28702 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15549338 | 0.90 | ADRB2 (0.74) | ADRB2ADRB1ADRB3CYP2D6TSHR | |
| Zenidolol SCHEMBL146178 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP2D6TSHR | |
| Zenidolol SCHEMBL29387637 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP2D6TSHR | |
| SCHEMBL875724 | 0.85 | ADRB2 (0.71) | ADRB2ADRB1ADRB3CYP2D6TSHR | |
| Zenidolol SCHEMBL15058356 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP2D6TSHR | |
| Zenidolol SCHEMBL29558331 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP2D6TSHR | |
| Zenidolol SCHEMBL8027938 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP2D6TSHR | |
| Zenidolol SCHEMBL14941581 | 0.85 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP2D6TSHR | |
| Zenidolol SCHEMBL31074300 | 0.84 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP2D6TSHR | |
| Zenidolol SCHEMBL5485188 | 0.84 | ADRB2 (1.00) | ADRB2ADRB1ADRB3CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003664-B1 | ALKANOLAMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-02-17 | — | — | EP | disclosed |
| US-4275058-A | 1-(7-METHYLINDAN-4-YLOXY)-3-ISOPROPYLAMINOBUTAN-2-OL | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-06-23 | — | — | US | disclosed |
| EP-0003664-A1 | Alkanolamine derivatives, process for their preparation and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-08-22 | — | — | EP | disclosed |