Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254917 | 0.91 | KDM4E (0.41) | KDM4EHSD17B10CNR2LMNATSHR | |
| Hydrochloric Acid SCHEMBL11251082 | 0.90 | KDM4E (0.41) | KDM4EHSD17B10CNR2LMNATSHR | |
| SCHEMBL11249243 | 0.89 | PPARA (0.42) | PLA2G2AKDM4EHSD17B10CNR2LMNA | |
| SCHEMBL11261761 | 0.88 | ADORA2A (0.38) | PLA2G2AKDM4EHSD17B10CNR2LMNA | |
| SCHEMBL11254185 | 0.87 | TRPM8 (0.38) | PLA2G2AKDM4EHSD17B10CNR2LMNA | |
| SCHEMBL11262943 | 0.87 | LMNA (0.39) | PLA2G2AKDM4EHSD17B10CNR2LMNA | |
| SCHEMBL11261247 | 0.85 | KDM4E (0.36) | PLA2G2AKDM4EHSD17B10CNR2LMNA | |
| Hydrochloric Acid SCHEMBL11265900 | 0.84 | KDM4E (0.48) | PLA2G2AKDM4EHSD17B10CNR2LMNA | |
| SCHEMBL11259439 | 0.83 | KDM4E (0.45) | PLA2G2AKDM4EHSD17B10CNR2LMNA | |
| SCHEMBL11267814 | 0.82 | HSD11B1 (0.40) | CNR2LMNATSHRNPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015523-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR MEDICAMENTS | Dr. Karl Thomae GmbH (DE) | 1982-10-13 | — | — | EP | disclosed |
| US-4343811-A | ATHEROSCLEROSIS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-10 | — | — | US | disclosed |
| EP-0015523-A1 | Indole derivatives, their preparation and their use for medicaments | Dr. Karl Thomae GmbH (DE) | 1980-09-17 | — | — | EP | disclosed |