Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.34 |
| ▸ | MAOA | P21397 | 5/20 | 0.34 |
| ▸ | MAOB | P27338 | 5/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3992251 | 0.80 | KDM1A (0.36) | KDM1AMAOAMAOBCHRNA7 | |
| SCHEMBL5458200 | 0.80 | — | — | |
| SCHEMBL1153469 | 0.78 | KDM1A (0.44) | KDM1AMAOAMAOBHTR2AHTR2C | |
| SCHEMBL1863590 | 0.78 | — | — | |
| SCHEMBL23203046 | 0.77 | CHRNA7 (0.31) | KDM1ACHRNA7 | |
| SCHEMBL20017698 | 0.77 | HTR2A (0.35) | KDM1AMAOAMAOBHTR2AHTR2C | |
| SCHEMBL13818654 | 0.77 | KDM1A (0.34) | KDM1AMAOAMAOBCHRNA7 | |
| SCHEMBL4609631 | 0.75 | MEN1 (0.34) | HTR2AHTR2CHTR2B | |
| SCHEMBL8410542 | 0.74 | ALDH1A1 (0.31) | KDM1AMAOAMAOB | |
| SCHEMBL734440 | 0.74 | KDM1A (0.38) | KDM1AMAOAMAOBHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021228-B1 | 4-SUBSTITUTED-3-HYDROXY-3-PYRROLINE-2,5-DIONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | MERCK & CO. INC. (US) | 1982-09-01 | — | — | EP | disclosed |
| EP-0021228-A1 | 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione compounds, process for their preparation and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1981-01-07 | — | — | EP | disclosed |