Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11248816 | 0.89 | HPGD (0.51) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| Hydrochloric Acid SCHEMBL11431914 | 0.87 | OPRK1 (0.56) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL10858544 | 0.82 | OPRK1 (0.38) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL11261476 | 0.80 | OPRK1 (0.45) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL10919992 | 0.77 | OPRK1 (0.51) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL10919997 | 0.77 | OPRK1 (0.51) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL7313742 | 0.77 | OPRK1 (0.54) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| Hydrochloric Acid SCHEMBL7348131 | 0.76 | GABRA1 (0.50) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL10918118 | 0.76 | OPRK1 (0.54) | OPRK1PDE4DGABRA1GABRA5GABRA2 | |
| SCHEMBL10918115 | 0.76 | OPRK1 (0.54) | OPRK1PDE4DGABRA1GABRA5GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4338314-A | [1,2]Anellated-7-phenyl-1,4-benzodiazepine and pharmaceutical compositions thereof and use for treatment of ulcers | KALI-CHEMIE PHARMA GMBH (DE) | 1982-07-06 | — | — | US | disclosed |