Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10144991 | 0.73 | CYP4F2 (0.69) | CYP1A2CYP2C19CYP4F2CYP4A11 | |
| SCHEMBL1126583 | 0.70 | JAK2 (0.48) | GABRB2JAK2JAK3CYP1A2CYP2C19 | |
| SCHEMBL31029 | 0.68 | JAK2 (0.57) | CLEC4MGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL1126789 | 0.68 | ALDH1A1 (0.52) | KDM4EJAK2JAK3CYP1A2CYP2C19 | |
| SCHEMBL22748388 | 0.67 | PPARA (0.49) | CYP4F2CYP4A11 | |
| SCHEMBL10982170 | 0.67 | MDM2 (0.54) | CLEC4MKDM4EJAK2JAK3PDE3B | |
| SCHEMBL1752519 | 0.66 | GRM1 (0.59) | CLEC4MGABRA1GABRB2KDM4ECYP1A2 | |
| SCHEMBL1149318 | 0.66 | MAPT (0.49) | KDM4E | |
| SCHEMBL2658905 | 0.66 | KDM4E (0.55) | CLEC4MGABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL662273 | 0.66 | CYP4F2 (0.74) | CYP1A2CYP2C19CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283006-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009130481-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2009-10-29 | — | — | WO | disclosed |