Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359531 | 0.74 | ALOX15 (0.69) | ALOX15HTTPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29924709 | 0.74 | ALOX15 (0.69) | ALOX15HTTPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2270839 | 0.73 | ALOX15 (0.64) | ALOX15HTTPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11264480 | 0.72 | KMT2A (0.60) | ALOX15HTTALDH1A1CYP3A4TSHR | |
| SCHEMBL13844834 | 0.71 | PLK1 (0.74) | ALOX15HTTPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11267948 | 0.71 | MAPT (0.51) | HTTALDH1A1SMN1; SMN2LMNANPC1 | |
| SCHEMBL27856105 | 0.70 | DOT1L (0.73) | ALOX15HTTPLK1ALDH1A1CYP3A4 | |
| SCHEMBL2696504 | 0.70 | PTPN1 (0.60) | ALOX15HTTPLK1ALDH1A1TSHR | |
| SCHEMBL11962154 | 0.70 | PLK1 (1.00) | ALOX15HTTPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4402960 | 0.70 | ALOX15 (0.63) | ALOX15HTTPLK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329363-A | Substituted mercapto acid amides and their use | MERCK & CO., INC. (US) | 1982-05-11 | — | — | US | disclosed |
| US-4216160-A | IMMUNOREGULANTS FOR CORRECTING AN INBALANCE OF IMMUNE HOMEOSTASIS | MERCK & CO., INC. (US) | 1980-08-05 | — | — | US | disclosed |