Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11267948 | 0.91 | MAPT (0.51) | KMT2AALDH1A1MAPTGPR139L3MBTL1 | |
| SCHEMBL12642206 | 0.82 | GPR139 (0.62) | KMT2AALDH1A1MAPTGPR139L3MBTL1 | |
| SCHEMBL9371115 | 0.81 | ALDH1A1 (0.51) | KMT2AALDH1A1MAPTGPR139L3MBTL1 | |
| SCHEMBL11266779 | 0.79 | KMT2A (0.40) | KMT2AALDH1A1MAPTGPR139L3MBTL1 | |
| SCHEMBL11267199 | 0.78 | SMN1; SMN2 (0.44) | KMT2AALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL9129277 | 0.77 | ALDH1A1 (0.75) | KMT2AALDH1A1MAPTGPR139L3MBTL1 | |
| SCHEMBL11259579 | 0.77 | PAM (0.62) | KMT2AALDH1A1L3MBTL1KDM4ECES1 | |
| SCHEMBL8980464 | 0.77 | GPR139 (0.60) | KMT2AALDH1A1MAPTGPR139L3MBTL1 | |
| SCHEMBL16088012 | 0.76 | KMT2A (0.50) | KMT2AALDH1A1MAPTGPR139L3MBTL1 | |
| SCHEMBL10101151 | 0.76 | KMT2A (0.56) | KMT2AALDH1A1MAPTGPR139L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329363-A | Substituted mercapto acid amides and their use | MERCK & CO., INC. (US) | 1982-05-11 | — | — | US | disclosed |
| US-4216160-A | IMMUNOREGULANTS FOR CORRECTING AN INBALANCE OF IMMUNE HOMEOSTASIS | MERCK & CO., INC. (US) | 1980-08-05 | — | — | US | disclosed |
| EP-0001989-A1 | Substituted mercapto acid amides, process for their preparation, pharmaceutical composition containing same and their use | MERCK & CO. INC. (US) | 1979-05-30 | — | — | EP | disclosed |