Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.51 |
| ▸ | ACE | P12821 | 5/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.34 |
| ▸ | Q9HBH1 | 2/20 | 0.32 | |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11260990 | 0.89 | ACE (0.47) | RENACE | |
| SCHEMBL11255102 | 0.87 | ACE (0.36) | RENACEABCB11 | |
| SCHEMBL11258386 | 0.83 | ABCB11 (0.39) | RENACEABCB11 | |
| SCHEMBL11266964 | 0.80 | REN (0.56) | RENACEABCB11HDAC8 | |
| SCHEMBL11269497 | 0.79 | ACE (0.34) | ACE | |
| SCHEMBL11304174 | 0.71 | — | — | |
| SCHEMBL11260996 | 0.69 | ACE (0.53) | RENACEABCB11HDAC8 | |
| SCHEMBL11563553 | 0.68 | REN (1.00) | RENACE | |
| SCHEMBL11255108 | 0.68 | ACE (0.53) | RENACEABCB11HDAC8 | |
| SCHEMBL11562206 | 0.66 | REN (0.67) | RENACEMMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049589-A1 | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4311705-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-01-19 | — | — | US | disclosed |