Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11260996 | 0.88 | ACE (0.53) | RENACEHDAC8ABCB11 | |
| SCHEMBL11255108 | 0.86 | ACE (0.53) | RENACEHDAC8ABCB11 | |
| SCHEMBL11212483 | 0.83 | ACE (0.53) | RENACEABCB11 | |
| SCHEMBL11216045 | 0.82 | ACE (0.53) | ACEHDAC8ABCB11 | |
| SCHEMBL11216048 | 0.82 | ACE (0.53) | ACEHDAC8ABCB11 | |
| SCHEMBL11258395 | 0.82 | ABCB11 (0.56) | RENACEHDAC8ABCB11 | |
| SCHEMBL11266960 | 0.80 | REN (0.51) | RENACEHDAC8ABCB11 | |
| SCHEMBL11211504 | 0.79 | ACE (0.50) | ACEHDAC8ABCB11 | |
| SCHEMBL9175072 | 0.79 | HDAC8 (0.56) | ACEHDAC8ABCB11 | |
| SCHEMBL9175083 | 0.79 | HDAC8 (0.56) | ACEHDAC8ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049589-A1 | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4311705-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-01-19 | — | — | US | disclosed |