Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 3/20 | 0.51 |
| ▸ | NMT1 | P30419 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | NMT2 | O60551 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15892266 | 0.95 | MEN1 (0.55) | MEN1KMT2AHSP90AA1GABRA1GABRG2 | |
| SCHEMBL111721 | 0.90 | MEN1 (0.53) | MEN1KMT2AHSP90AA1GABRA1GABRG2 | |
| SCHEMBL3534571 | 0.85 | LMNA (0.55) | MEN1KMT2ALMNAMAOBALDH1A1 | |
| SCHEMBL4400182 | 0.82 | KMT2A (0.67) | MEN1KMT2AHSP90AA1GABRA1GABRG2 | |
| SCHEMBL5035686 | 0.82 | MAOB (0.59) | MEN1KMT2ALMNAL3MBTL1CYP1A2 | |
| SCHEMBL226698 | 0.82 | P4HTM (0.69) | MEN1KMT2AHSP90AA1GABRA1GABRG2 | |
| SCHEMBL3532550 | 0.82 | LMNA (0.55) | MEN1KMT2ALMNAMAOBALDH1A1 | |
| SCHEMBL14278777 | 0.82 | MEN1 (0.65) | MEN1KMT2ALMNACYP1A2MAOB | |
| SCHEMBL5004775 | 0.81 | CYP1A2 (0.60) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL20944487 | 0.81 | MEN1 (0.60) | MEN1KMT2AHSP90AA1GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969549-B2 | Antioxidant small molecules aimed at targeting metal-based oxidative stress in neurogenerative disorders | TEXAS CHRISTIAN UNIVERSITY (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969549-B2 | Antioxidant small molecules aimed at targeting metal-based oxidative stress in neurogenerative disorders | TEXAS CHRISTIAN UNIVERSITY (US) | 2015-03-03 | — | — | US | disclosed |
| US-20140206862-A1 | Antioxidant Small Molecules Aimed at Targeting Metal-Based Oxidative Stress in Neurogenerative Disorders | TEXAS CHRISTIAN UNIVERSITY (US) | 2014-07-24 | — | — | US | disclosed |
| WO-2014113624-A1 | ANTIOXIDANT SMALL MOLECULES AIMED AT TARGETING METAL-BASED OXIDATIVE STRESS IN NEURODEGNERATIVE DISORDERS | TEXAS CHRISTIAN UNIVERSITY (US) | 2014-07-24 | — | — | WO | disclosed |
| US-20140206862-A1 | Antioxidant Small Molecules Aimed at Targeting Metal-Based Oxidative Stress in Neurogenerative Disorders | TEXAS CHRISTIAN UNIVERSITY (US) | 2014-07-24 | — | — | US | disclosed |
| EP-2424860-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | MSD K.K. (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | MSD K.K. (JP) | 2012-02-02 | — | — | US | disclosed |
| US-20110015181-A1 | ALKYLAMINOPYRIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-01-20 | — | — | US | disclosed |
| EP-2264026-A1 | ALKYLAMINOPYRIDINE DERIVATIVE | Banyu Pharmaceutical Co., Ltd. (JP) | 2010-12-22 | — | — | EP | disclosed |
| WO-2010126163-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028970-A1 | HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE | AR, NR5A1, ARL1 | MEN1 681/4885KMT2A 1493/4885HSP90AA1 1772/4885 |
| US-20140206862-A1 | Antioxidant Small Molecules Aimed at Targeting Metal-Based Oxidative Stress in Neurogenerative Disorders | PYCR1, PRNP, NLN | MEN1 890/4885KMT2A 3463/4885HSP90AA1 2581/4885 |
| US-20110015181-A1 | ALKYLAMINOPYRIDINE DERIVATIVE | NPY4R, NPY1R, NPY2R | MEN1 1674/4885KMT2A 3144/4885HSP90AA1 3494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.