Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.33 |
| ▸ | MERTK | Q12866 | 10/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 8/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 8/20 | 0.31 |
| ▸ | GAS6 | Q14393 | 8/20 | 0.31 |
| ▸ | AXL | P30530 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266023 | 0.92 | MERTK (0.36) | MERTKFLT3TYRO3GAS6AXL | |
| SCHEMBL11396125 | 0.90 | MERTK (0.39) | KCNH3MERTKP2RX3P2RX2KDR | |
| SCHEMBL10998512 | 0.85 | MAPT (0.37) | MERTKFLT3TYRO3GAS6AXL | |
| SCHEMBL11158821 | 0.84 | P2RX3 (0.42) | KCNH3MERTKP2RX3P2RX2JAK2 | |
| SCHEMBL10996367 | 0.82 | TLR8 (0.43) | MERTKFLT3TYRO3GAS6AXL | |
| SCHEMBL11432081 | 0.82 | TSHR (0.43) | MERTKFLT3TYRO3GAS6 | |
| SCHEMBL11002056 | 0.79 | KMT2A (0.43) | KCNH3MERTKJAK1JAK3FLT3 | |
| SCHEMBL10998571 | 0.79 | KMT2A (0.43) | KCNH3MERTKJAK1JAK3FLT3 | |
| SCHEMBL11236452 | 0.78 | KCNH3 (0.43) | KCNH3MERTKP2RX3P2RX2JAK3 | |
| SCHEMBL11000318 | 0.78 | CYP1A2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016374-B1 | PENICILLINS, THEIR SALTS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1982-03-03 | — | — | EP | disclosed |
| US-4289775-A | BACTERICIDAL ANTIBIOTICS | KARL THOMAE GMBH (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0016374-A1 | Penicillins, their salts, process for their preparation and therapeutic agents containing these compounds | Dr. Karl Thomae GmbH (DE) | 1980-10-01 | — | — | EP | disclosed |