Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 5/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 3/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427824 | 0.81 | SIGMAR1 (0.74) | SIGMAR1SLC6A3SLC6A2 | |
| SCHEMBL11261994 | 0.81 | ALDH1A1 (0.61) | HRH3SIGMAR1HTR2AALDH1A1 | |
| SCHEMBL10212375 | 0.79 | ALDH1A1 (0.58) | HRH3SIGMAR1HTR2AALDH1A1 | |
| SCHEMBL28001277 | 0.78 | KCNH2 (0.79) | HRH3SIGMAR1SLC6A3KCNH2ALDH1A1 | |
| SCHEMBL6573503 | 0.78 | HRH3 (0.96) | HRH3SIGMAR1SLC6A3HTR2AHTR2C | |
| SCHEMBL12073194 | 0.78 | ALDH1A1 (0.68) | HRH3SIGMAR1SLC6A3HTR2AKCNH2 | |
| SCHEMBL8673775 | 0.78 | SIGMAR1 (0.65) | HRH3SIGMAR1SLC6A3HTR2AKCNH2 | |
| SCHEMBL791561 | 0.78 | HRH3 (0.61) | HRH3SIGMAR1SLC6A3KCNH2TAAR1 | |
| Hydrochloric Acid SCHEMBL11093610 | 0.76 | SIGMAR1 (0.63) | HRH3SIGMAR1SLC6A3HTR2AKCNH2 | |
| SCHEMBL9254022 | 0.76 | HRH3 (0.62) | HRH3SIGMAR1SLC6A3KCNH2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360511-A | Amines useful as brain imaging agents | MEDI-PHYSICS, INC. (US) | 1982-11-23 | — | — | US | disclosed |
| EP-0011858-A1 | Radioiodine containing amines, their preparation and their use as brain imaging agents | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-06-11 | — | — | EP | disclosed |