SCHEMBL6573503

SCHEMBL6573503

Oc1ccccc1CCN1CCCCC1

nearest known ligand 0.96

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 5/20 0.96
SIGMAR1 Q99720 2/20 0.56
MPO P05164 2/20 0.56
KDM4E B2RXH2 1/20 0.56
HTR2A P28223 3/20 0.55
HTR2C P28335 1/20 0.55
HTR2B P41595 1/20 0.55
SLC6A3 Q01959 1/20 0.53
KCNH2 Q12809 1/20 0.49
ALDH1A1 P00352 1/20 0.48
GAA P10253 1/20 0.48
MAPT P10636 1/20 0.48
PKM P14618 1/20 0.48
ALOX15 P16050 1/20 0.48
TAAR1 Q96RJ0 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27678708 0.98 HRH3 (1.00) HRH3SIGMAR1MPOKDM4EHTR2A
SCHEMBL19043541 0.87 HRH3 (0.80) HRH3SIGMAR1MPOKDM4EHTR2A
SCHEMBL10454920 0.82 HRH3 (0.72) HRH3SIGMAR1MPOKDM4EKCNH2
SCHEMBL7946364 0.81 MPO (0.81) HRH3MPOKDM4EALDH1A1GAA
SCHEMBL10415354 0.79 MPO (0.84) HRH3MPOKDM4EALDH1A1GAA
SCHEMBL5139433 0.78 HRH3 (0.61) HRH3SIGMAR1MPOKDM4EALDH1A1
SCHEMBL28001277 0.78 KCNH2 (0.79) HRH3SIGMAR1KDM4ESLC6A3KCNH2
SCHEMBL11267644 0.78 HRH3 (0.61) HRH3SIGMAR1HTR2AHTR2CSLC6A3
SCHEMBL8673775 0.78 SIGMAR1 (0.65) HRH3SIGMAR1HTR2ASLC6A3KCNH2
SCHEMBL791561 0.78 HRH3 (0.61) HRH3SIGMAR1SLC6A3KCNH2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1361851-A4 PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR P & G CLAIROL INC (US) 2004-12-15 EP disclosed
EP-1361851-A1 PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR P & G-Clairol, Inc. (US) 2003-11-19 EP disclosed
US-6534525-B1 Method of using 2- substituted piperidine analogs as selectively active antagonist of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, WARNER-LAMBERT & COMPANY 2003-03-18 US disclosed
WO-2002058653-A1 PRIMARY INTERMEDIATES FOR OXIDATIVE COLORATION OF HAIR P&G CLAIROL, INC. (US) 2002-08-01 WO disclosed
US-6124317-A ACTIVE DRUG TREATING STROKE, CEREBRAL ISCHEMIA, CENTRAL NERVOUS SYSTEM TRAUMA, HYPOGLYCEMIA, ANXIETY, CONVULSIONS, AMIOGLYCOSIDE ANTIBIOTICS-INDUCED HEARING LOSS, MIGRAINE HEADACHES, CHRONIC PAIN, GLAUCOMA, CMV RETINITIS, PSYCHOSIS WARNER-LAMBERT COMPANY (US) 2000-09-26 US disclosed
WO-1997023215-A1 2-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE-SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1997-07-03 WO disclosed