Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.54 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.54 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | ALB | P02768 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | RARB | P10826 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.54 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1260765 | 0.80 | FAAH (0.52) | ADRB3HTR2AFAAH | |
| SCHEMBL1261060 | 0.76 | PTGS2 (0.53) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL30935729 | 0.72 | CYP17A1 (0.36) | ADRB3FAAH | |
| SCHEMBL15726346 | 0.72 | TSHR (0.76) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL4408253 | 0.71 | CXCR1 (0.79) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| Ibuprofen SCHEMBL19439560 | 0.71 | PTGS1 (1.00) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| Ibuprofen SCHEMBL3001 | 0.71 | PTGS1 (1.00) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| Ibuprofen SCHEMBL239446 | 0.71 | PTGS1 (1.00) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL4471196 | 0.71 | CXCR1 (0.79) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| Ibuprofen SCHEMBL8754799 | 0.71 | PTGS1 (1.00) | PTGS2PTGS1LMNACYP2C9AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4362738-A | ANTIINFLAMMATORIES | DR. KARL THOMAE GMBH (DE) | 1982-12-07 | — | — | US | disclosed |