Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK3 | P35626 | 3/20 | 0.62 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TLR4 | O00206 | 1/20 | 0.48 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11267040 | 0.87 | DRD2 (0.59) | GRK3DRD2DRD4DRD3ADRB2 | |
| SCHEMBL11255470 | 0.86 | DRD2 (0.58) | GRK3DRD2DRD4DRD3ADRB2 | |
| SCHEMBL11266544 | 0.85 | ADRB2 (0.67) | GRK3DRD2DRD4DRD3ADRB2 | |
| SCHEMBL17945782 | 0.82 | ADRB2 (0.72) | GRK3DRD2DRD4DRD3ADRB2 | |
| SCHEMBL11260559 | 0.81 | DRD2 (0.53) | GRK3DRD2DRD4DRD3ADRB2 | |
| SCHEMBL22279167 | 0.80 | GRK3 (0.73) | GRK3DRD2DRD4DRD3ADRB2 | |
| SCHEMBL11270888 | 0.80 | GAA (0.52) | DRD2DRD4DRD3ADRB2MAPT | |
| SCHEMBL11146826 | 0.80 | DRD2 (0.55) | DRD2DRD4DRD3ADRB2MAPT | |
| SCHEMBL11259392 | 0.78 | ADRB3 (0.50) | DRD2DRD4DRD3ADRB2MAPT | |
| SCHEMBL11115106 | 0.77 | ADRB1 (0.45) | DRD2DRD4DRD3ADRB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346093-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1982-08-24 | — | — | US | disclosed |