Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.50 |
| ▸ | GCGR | P47871 | 12/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | FRK | P42685 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11481381 | 0.88 | NPY5R (0.48) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5435606 | 0.83 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4285506 | 0.82 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5098384 | 0.82 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9741082 | 0.82 | NPY5R (0.51) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL11264987 | 0.79 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL15075635 | 0.78 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL1116552 | 0.74 | CYP11B1 (0.54) | CYP19A1CYP11B1KDM4EALDH1A1LMNA | |
| SCHEMBL9646725 | 0.74 | KDM4E (0.58) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL11272961 | 0.74 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008755-B1 | ANTIINFLAMMATORY 4,5-DIARYL-2-NITROIMIDAZOLES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-04-21 | — | — | EP | disclosed |
| US-4251535-A | ANTIARTHRITIC AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-02-17 | — | — | US | disclosed |
| US-4199592-A | Antiinflammatory 4,5-diaryl-2-nitroimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-04-22 | — | — | US | disclosed |
| EP-0008755-A1 | Antiinflammatory 4,5-diaryl-2-nitroimidazoles, method for their preparation and pharmaceutical composition containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-03-19 | — | — | EP | disclosed |