Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.69 |
| ▸ | GCGR | P47871 | 11/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.69 |
| ▸ | FRK | P42685 | 3/20 | 0.69 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.69 |
| ▸ | GSK3B | P49841 | 3/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.69 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.69 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.62 |
| ▸ | BRAF | P15056 | 2/20 | 0.62 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.61 |
| ▸ | RAF1 | P04049 | 2/20 | 0.61 |
| ▸ | PRKACA | P17612 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5098384 | 1.00 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5435606 | 0.92 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9435546 | 0.90 | MAPK13 (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL15075603 | 0.82 | MAPK11 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL19868925 | 0.82 | MAPK11 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL11267958 | 0.82 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL27335373 | 0.81 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6168758 | 0.81 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9340175 | 0.80 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9339561 | 0.80 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090098536-A1 | Method for subgroup analysis in subjects having or being suspected of having inflammatory disease, use of anti-p38MAPK antibodies, kits and their use | C-A-I-R- BIOSCIENCES GMBH (DE) | 2009-04-16 | — | — | US | disclosed |
| US-7442713-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| EP-1909102-A1 | Method for subgroup analysis in subjects having or being suspected of having inflammatory disease, use of anti-p38mapk antibodies, kits and their use | c-a-i-r biosciences GmbH (DE) | 2008-04-09 | — | — | EP | disclosed |
| EP-0994858-A1 | 2-SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2000-04-26 | — | — | EP | disclosed |
| US-6040320-A | ANTIINFLAMMATORY AGENT FOR TREATING DISEASES ASSOCIATED WITH OVERPRODUCTION OF INFLAMMATORY CYTOKINES, SUCH AS RHEUMATOID ARTHRITIS, INFLAMMATORY BOWEL DISEASE, SEPTIC SHOCK, OSTEOPOROSIS, AND OSTEOARTHRITIS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-03-21 | — | — | US | disclosed |
| WO-1999003837-A1 | 2-SUBSTITUTED IMIDAZOLES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 1999-01-28 | — | — | WO | disclosed |
| EP-0321490-B1 | INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES | SMITHKLINE BEECHAM CORP (US) | 1994-06-22 | — | — | EP | disclosed |
| EP-0321490-A4 | INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES. | SMITHKLINE BECKMAN CORP (US) | 1990-05-14 | — | — | EP | disclosed |
| EP-0321490-A1 | INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES. | SMITHKLINE BECKMAN CORP (US) | 1989-06-28 | — | — | EP | disclosed |
| WO-1988001167-A1 | INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | disclosed |
| WO-1988001169-A1 | INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | disclosed |
| US-4175127-A | ANTIARTHRITIC AGENTS | SMITHKLINE CORPORATION (US) | 1979-11-20 | — | — | US | disclosed |