Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 13/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 13/20 | 0.69 |
| ▸ | GCGR | P47871 | 11/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.69 |
| ▸ | FRK | P42685 | 3/20 | 0.69 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.69 |
| ▸ | GSK3B | P49841 | 3/20 | 0.69 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.69 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.69 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.62 |
| ▸ | BRAF | P15056 | 2/20 | 0.62 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.61 |
| ▸ | RAF1 | P04049 | 2/20 | 0.61 |
| ▸ | PRKACA | P17612 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285506 | 1.00 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5435606 | 0.92 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9435546 | 0.90 | MAPK13 (0.56) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL15075603 | 0.82 | MAPK11 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL19868925 | 0.82 | MAPK11 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL11267958 | 0.82 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL27335373 | 0.81 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6168758 | 0.81 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9340175 | 0.80 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9339561 | 0.80 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0011111-B1 | 5-(4-PYRIDYL)-6-(4-FLUOROPHENYL)-2,3-DIHYDROIMIDAZO-(2,1-B)-THIAZOLE, PROCESS FOR ITS PREPARATION AND MEDICAL COMPOSITION | SMITHKLINE BECKMAN CORPORATION (US) | 1982-09-22 | — | — | EP | claimed |
| EP-0011111-A1 | 5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo-(2,1-b)-thiazole, process for its preparation and medical composition | SMITHKLINE BECKMAN CORPORATION (US) | 1980-05-28 | — | — | EP | claimed |
| US-7442713-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-20060252810-A1 | 2-Thio-substituted imidazole derivatives and their use in pharmaceutics | LAUFER STEFAN | 2006-11-09 | — | — | US | disclosed |
| EP-1506187-A1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS | MERCKLE GMBH (DE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097633-A1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS | MERCKLE GMBH (DE) | 2003-11-27 | — | — | WO | disclosed |
| EP-0011111-B1 | 5-(4-PYRIDYL)-6-(4-FLUOROPHENYL)-2,3-DIHYDROIMIDAZO-(2,1-B)-THIAZOLE, PROCESS FOR ITS PREPARATION AND MEDICAL COMPOSITION | SMITHKLINE BECKMAN CORPORATION (US) | 1982-09-22 | — | — | EP | disclosed |
| EP-0011111-A1 | 5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo-(2,1-b)-thiazole, process for its preparation and medical composition | SMITHKLINE BECKMAN CORPORATION (US) | 1980-05-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252810-A1 | 2-Thio-substituted imidazole derivatives and their use in pharmaceutics | IL2, TPMT, IFNG | MAPK14 3913/4885MAPK13 3863/4885MAPK12 3593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.