Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.70 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.70 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.70 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.70 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.70 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.70 |
| ▸ | CHRNG | P07510 | 4/20 | 0.70 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.70 |
| ▸ | CHRND | Q07001 | 4/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL896456 | 0.98 | SLC6A2 (0.68) | SLC6A2SLC6A3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL17644180 | 0.98 | SLC6A2 (0.68) | SLC6A2SLC6A3CHRNB2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL22614717 | 0.97 | SLC6A2 (0.66) | SLC6A2SLC6A3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL11270333 | 0.84 | HPGD (0.61) | SLC6A2SLC6A3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6811754 | 0.82 | ALDH1A1 (0.61) | SLC6A2SLC6A3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8198232 | 0.81 | SLC6A2 (0.55) | SLC6A2SLC6A3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL5953978 | 0.81 | SLC6A2 (0.68) | SLC6A2SLC6A3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9796926 | 0.81 | SLC6A3 (0.60) | SLC6A2SLC6A3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9360364 | 0.81 | SLC6A3 (0.60) | SLC6A2SLC6A3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL11265978 | 0.81 | SLC6A2 (0.65) | SLC6A2SLC6A3CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4361573-A | α,α-Diaryl-β-(tert-amino)-propanols and diuretic pharmaceutical compositions containing them | TEMMLER AG (CH) | 1982-11-30 | — | — | US | disclosed |
| US-4025633-A | DIURETICS, SALURETICS | FIRMA TEMMLER A.G. (CH) | 1977-05-24 | — | — | US | disclosed |