Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.57 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.57 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.57 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.57 |
| ▸ | CHRNG | P07510 | 4/20 | 0.57 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.57 |
| ▸ | CHRND | Q07001 | 4/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9796926 | 1.00 | SLC6A3 (0.60) | SLC6A3ALDH1A1KDM4EGAASLC6A2 | |
| Hydrochloric Acid SCHEMBL9796810 | 0.98 | SLC6A3 (0.58) | SLC6A3ALDH1A1KDM4EGAASLC6A2 | |
| Hydrochloric Acid SCHEMBL9797234 | 0.98 | SLC6A3 (0.58) | SLC6A3ALDH1A1KDM4EGAASLC6A2 | |
| SCHEMBL9597385 | 0.98 | SLC6A3 (0.61) | SLC6A3ALDH1A1KDM4EGAASLC6A2 | |
| Hydrochloric Acid SCHEMBL9596538 | 0.97 | SLC6A3 (0.60) | SLC6A3ALDH1A1KDM4EGAASLC6A2 | |
| SCHEMBL9597221 | 0.85 | SLC6A3 (0.48) | SLC6A3ALDH1A1KDM4EGAASLC6A2 | |
| SCHEMBL6811754 | 0.85 | ALDH1A1 (0.61) | SLC6A3ALDH1A1KDM4EGAASLC6A2 | |
| SCHEMBL10701944 | 0.84 | MEN1 (0.48) | SLC6A3ALDH1A1KDM4EGAASLC6A2 | |
| SCHEMBL10469275 | 0.84 | HRH3 (0.49) | SLC6A3ALDH1A1KDM4EGAASLC6A2 | |
| SCHEMBL5953978 | 0.83 | SLC6A2 (0.68) | SLC6A3ALDH1A1KDM4EGAASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236922-A | Method for treating depression using 1-(aminophenyl)-2-aminopropanone derivatives | LABORATOIRE L. LAFON (FR) | 1993-08-17 | — | — | US | claimed |
| JP-3209364-A | — | — | None | — | — | JP | disclosed |
| EP-0426562-B1 | 1-(4-Aminophenyl)-2-piperidinopropanone derivatives, process for their preparation and their therapeutic use | LAFON LABOR (FR) | 1994-03-16 | — | — | EP | disclosed |
| EP-0426562-B1 | 1-(4-Aminophenyl)-2-piperidinopropanone derivatives, process for their preparation and their therapeutic use | LAFON LABOR (FR) | 1994-03-16 | — | — | EP | disclosed |
| US-5128349-A | Vasodilators; cardiovascular disorders | LABORATOIRE L. LAFON (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5128349-A | Vasodilators; cardiovascular disorders | LABORATOIRE L. LAFON (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5128349-A | Vasodilators; cardiovascular disorders | LABORATOIRE L. LAFON (FR) | 1992-07-07 | — | — | US | disclosed |
| JP-H03209364-A | 1-(4AMINOPHENYL)2-PIPERIDINOPROPANONE DERIVATIVE, PREPARATION PROCESS AND USE IN THERAPEUTICS | LAB L LAFON SA | 1991-09-12 | — | — | JP | disclosed |
| EP-0426562-A1 | 1-(4-Aminophenyl)-2-piperidinopropanone derivatives, process for their preparation and their therapeutic use | LABORATOIRE L. LAFON (FR) | 1991-05-08 | — | — | EP | disclosed |
| EP-0426562-A1 | 1-(4-Aminophenyl)-2-piperidinopropanone derivatives, process for their preparation and their therapeutic use | LABORATOIRE L. LAFON (FR) | 1991-05-08 | — | — | EP | disclosed |
| EP-0426562-A1 | 1-(4-Aminophenyl)-2-piperidinopropanone derivatives, process for their preparation and their therapeutic use | LABORATOIRE L. LAFON (FR) | 1991-05-08 | — | — | EP | disclosed |
| EP-0328460-A2 | 1-(4-Aminophenyl)-2-hexamethyleniminopropanone, process for its preparation and its therapeutical use | LABORATOIRE L. LAFON (FR) | 1989-08-16 | — | — | EP | disclosed |