Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.41 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11268555 | 0.86 | HTR7 (0.47) | GAAHTR7MAPTSMN1; SMN2LMNA | |
| SCHEMBL11270591 | 0.80 | CNR2 (0.50) | MAPTSMN1; SMN2LMNAL3MBTL1MEN1 | |
| SCHEMBL11267467 | 0.79 | HTR7 (0.41) | POLBHTR7MAPTSMN1; SMN2LMNA | |
| SCHEMBL2951932 | 0.69 | RAB9A (0.52) | GAAHTR7MAPTSMN1; SMN2LMNA | |
| SCHEMBL12152159 | 0.69 | CNR2 (0.40) | GAAPOLBMAPTSMN1; SMN2LMNA | |
| SCHEMBL9273102 | 0.69 | POLB (0.52) | GAAPOLBMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL27199775 | 0.67 | LMNA (0.49) | GAAHTR7LMNAMEN1KMT2A | |
| SCHEMBL12743209 | 0.66 | MAPT (0.39) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL2957488 | 0.66 | HTR7 (0.53) | GAAPOLBHTR7MAPTSMN1; SMN2 | |
| SCHEMBL7995686 | 0.66 | TEK (0.58) | GAAMAPTSMN1; SMN2LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1281561-C | Compound with base skeleton of 1,6-methylene-[10]-annulene and use thereof | SHANGHAI INST ORGANIC CHEM (CN) | 2006-10-25 | — | — | CN | disclosed |
| CN-1450032-A | Compound with base skeleton of 1,6-methylene-[10]-annulene and use thereof | SHANGHAI INST ORGANIC CHEM (CN) | 2003-10-22 | — | — | CN | disclosed |
| EP-0008755-B1 | ANTIINFLAMMATORY 4,5-DIARYL-2-NITROIMIDAZOLES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-04-21 | — | — | EP | disclosed |
| US-4251535-A | ANTIARTHRITIC AGENTS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-02-17 | — | — | US | disclosed |
| US-4199592-A | Antiinflammatory 4,5-diaryl-2-nitroimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-04-22 | — | — | US | disclosed |
| EP-0009008-A2 | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-03-19 | — | — | EP | disclosed |
| EP-0008755-A1 | Antiinflammatory 4,5-diaryl-2-nitroimidazoles, method for their preparation and pharmaceutical composition containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-03-19 | — | — | EP | disclosed |