Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | SCN4A | P35499 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9833415 | 0.86 | SMN1; SMN2 (0.46) | NLRP3ALDH1A1MAPTHSD17B10HTT | |
| SCHEMBL11435633 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MAPTHSD17B10LMNACYP3A4 | |
| SCHEMBL11674507 | 0.78 | NLRP3 (0.49) | NLRP3ALDH1A1MAPTCYP3A4TDP1 | |
| SCHEMBL6486619 | 0.78 | SMN1; SMN2 (0.54) | ALDH1A1MEN1KMT2AGAATSHR | |
| SCHEMBL9831398 | 0.77 | SMN1; SMN2 (0.47) | NLRP3ALDH1A1MAPTHSD17B10HTT | |
| SCHEMBL9205663 | 0.76 | ALDH1A1 (0.57) | NLRP3ALDH1A1MAPTHSD17B10HTT | |
| SCHEMBL14156361 | 0.76 | SMN1; SMN2 (0.47) | NLRP3ALDH1A1MAPTHSD17B10HTT | |
| SCHEMBL10935007 | 0.75 | ALDH1A1 (0.40) | ALDH1A1MAPTLMNACYP3A4MAPK1 | |
| SCHEMBL18055614 | 0.75 | TDP1 (0.53) | ALDH1A1MAPTLMNATDP1MEN1 | |
| SCHEMBL8415298 | 0.75 | ALDH1A1 (0.63) | NLRP3ALDH1A1MAPTHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322434-A | N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1982-03-30 | — | — | US | disclosed |
| US-4267193-A | N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1981-05-12 | — | — | US | disclosed |