Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | CDC25C | P30307 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | FABP2 | P12104 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126731 | 0.82 | MMP1 (0.41) | SMN1; SMN2HSD17B10ALDH1A1PTGS1MEN1 | |
| SCHEMBL1126982 | 0.78 | TP53 (0.35) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1990353 | 0.77 | MEN1 (0.44) | HSD17B10ALDH1A1ALOX15MEN1KMT2A | |
| SCHEMBL23488097 | 0.77 | THRB (0.40) | SMN1; SMN2KDM4EALDH1A1PTGS1MEN1 | |
| SCHEMBL15162096 | 0.77 | THRB (0.39) | SMN1; SMN2KDM4EHSD17B10CDC25APTGS1 | |
| SCHEMBL1993901 | 0.76 | KDM4E (0.41) | SMN1; SMN2KDM4EHSD17B10ALDH1A1PTGS1 | |
| SCHEMBL1126712 | 0.75 | HTT (0.39) | SMN1; SMN2KDM4EHSD17B10ALDH1A1KMT2A | |
| SCHEMBL1127116 | 0.74 | LMNA (0.42) | SMN1; SMN2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3884110 | 0.73 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EALDH1A1PTGS1MEN1 | |
| SCHEMBL1127378 | 0.73 | HPGD (0.41) | SMN1; SMN2HSD17B10ALDH1A1ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283006-B1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2015-02-25 | — | — | EP | disclosed |
| EP-2626361-B1 | Pyrrole antifungal agents | F2G LTD (GB) | 2014-10-15 | — | — | EP | disclosed |
| EP-2626361-A1 | Pyrrole antifungal agents | F2G Limited (GB) | 2013-08-14 | — | — | EP | disclosed |
| EP-2283006-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009130481-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2009-10-29 | — | — | WO | disclosed |