Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11264221 | 0.84 | NPC1 (0.45) | MAPTALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL11256671 | 0.83 | RAB9A (0.49) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4509401 | 0.82 | RAB9A (0.50) | MAPTALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL11271738 | 0.82 | MAPT (0.48) | MAPTALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL11262236 | 0.80 | MAPT (0.47) | MAPTALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL11262589 | 0.79 | MAPT (0.48) | MAPTALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL4493348 | 0.78 | CASP2 (0.55) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL11259059 | 0.77 | MAPT (0.44) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL11261115 | 0.74 | MAPT (0.51) | MAPTALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL11264138 | 0.73 | RAB9A (0.48) | ALDH1A1RAB9ASMN1; SMN2NPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4344946-A | ANTIARTHRITICS, ANTIRHEUMATICS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-17 | — | — | US | disclosed |