Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | CASP2 | P42575 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11269347 | 0.84 | MAPT (0.45) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11266789 | 0.82 | MAPT (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11256671 | 0.81 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL11269297 | 0.81 | SMN1; SMN2 (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4509401 | 0.80 | RAB9A (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL4493348 | 0.76 | CASP2 (0.55) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11259059 | 0.75 | MAPT (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL11261115 | 0.72 | MAPT (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11259222 | 0.71 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11264138 | 0.71 | RAB9A (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4344946-A | ANTIARTHRITICS, ANTIRHEUMATICS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-17 | — | — | US | disclosed |