Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5721986 | 0.74 | ALPG (0.47) | IDO1ERCC5FEN1USP2CXCR3 | |
| SCHEMBL11042469 | 0.74 | TRPA1 (0.39) | TSHRPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL29669994 | 0.73 | ALPG (0.63) | KMT2A | |
| SCHEMBL28549268 | 0.73 | ALPG (0.63) | KMT2A | |
| SCHEMBL5721975 | 0.72 | CA12 (0.51) | ERCC5FEN1CXCR3ALDH1A1 | |
| SCHEMBL5722000 | 0.72 | ALPG (0.45) | IDO1ERCC5FEN1CXCR3TSHR | |
| SCHEMBL5721917 | 0.71 | ALPG (0.46) | IDO1ERCC5FEN1CXCR3KMT2A | |
| SCHEMBL1155881 | 0.71 | ALDH1A1 (0.42) | KMT2APOLBALDH1A1 | |
| SCHEMBL11964124 | 0.70 | LMNA (0.38) | TSHRPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL401800 | 0.69 | GSK3B (0.57) | IDO1ERCC5FEN1USP2CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0044704-A1 | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1982-01-27 | — | — | EP | disclosed |